Emmitt Smith had the most games by a running back with 100+ rushing yards, with 78 games.

which rb has the most games with 100 yards
Interpreted as:
Which rb has the most regular-season games with 100 or more rushing yards?
SmithPaytonSandersDickersonBettisJamesMartinPetersonTaylorTomlinsonHarrisThomasGoreDorsettPortisSimpsonFaulkJohnsonCampbellDillonBrownMcCoyBarber7877766461575756494747464545444241404039393838
NAMEGPRUSH YDSATTYPCRUSH YDS/GRUSH TDREC YDSRECTRGAVGREC YDS/GREC TD
Emmitt SmithEmmitt Smith789,9771,9625.1127.9851,313219466.016.86
Walter PaytonWalter Payton7710,2531,9405.3133.2701,7701859.623.06
Barry SandersBarry Sanders7610,6541,7336.1140.2671,2841618.016.94
Eric DickersonEric Dickerson648,8131,6655.3137.7611,0121278.015.82
Jerome BettisJerome Bettis617,4801,5914.7122.63949565277.68.10
Edgerrin JamesEdgerrin James576,9761,4814.7122.4491,4871852328.026.16
Curtis MartinCurtis Martin577,3821,4944.9129.5481,1441561237.320.16
Adrian PetersonAdrian Peterson568,0281,3525.9143.461782931328.414.03
Fred TaylorFred Taylor496,3571,1145.7129.7399601081188.919.62
LaDainian TomlinsonLaDainian Tomlinson476,7061,1575.8142.7801,1181732376.523.87
Franco HarrisFranco Harris475,6271,0645.3119.749703878.115.02
Thurman ThomasThurman Thomas465,6661,1125.1123.2321,20512110.026.210
Frank GoreFrank Gore455,6989915.7126.6268521041478.218.93
Tony DorsettTony Dorsett455,7521,0065.7127.8401,0119510.622.55
Clinton PortisClinton Portis445,8771,1095.3133.645797881199.118.13
O.J. SimpsonO.J. Simpson426,2481,0655.9148.8354995010.011.95
Marshall FaulkMarshall Faulk415,5959086.2136.5501,7861861649.643.68
Chris JohnsonChris Johnson405,3959036.0134.942809951288.520.22
Earl CampbellEarl Campbell405,7031,1275.1142.645267465.86.70
Corey DillonCorey Dillon395,2729455.6135.23358678907.515.03
Jim BrownJim Brown395,6758936.4145.5431,0768712.427.611
LeSean McCoyLeSean McCoy385,0518226.1132.936548961145.714.43
Tiki BarberTiki Barber385,1548426.1135.6241,2211411848.732.13
Shaun AlexanderShaun Alexander375,2089525.5140.86045966997.012.46
Jamal LewisJamal Lewis365,0419245.5140.02650760798.514.11
StatMuse has game-level data for rushing yards going back to the 1960 season.