Peyton Manning has the most career passing touchdowns, with 539 touchdowns.

who did peyton manning throw the most touchdowns to
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NAMEGPTDCMPATTPCTYDSAVGYDS/GTD%INTINT%SCKSCKYRATE
Peyton ManningPeyton Manning2665396,1259,38065.371,9407.7270.55.72512.73031,95396.5
StatMuse has season-level data for passing touchdowns going back to the 1921 season.