Drew Brees had the most passing yards per game when playing 120+ games, with 280.0 per game.

who has the highest passing yards per game with at least 120 career games
BreesStaffordRyanManningBradyWarnerRodgersRiversRoethlisbergerPalmerMarinoManningFavreFoutsGreenMoonWilsonDaltonFlaccoBledsoeCutlerNewtonMcNabb280.0273.4272.0270.5263.1260.8260.1260.0259.0254.1253.6241.6237.9237.8237.3237.1235.7234.5232.6230.0229.6226.4223.2
NAMEGPYDS/GCMPATTPCTYDSAVGTDTD%INTINT%SCKSCKYRATE
Drew BreesDrew Brees287280.07,14210,55167.780,3587.65715.42432.34202,99198.7
Matthew StaffordMatthew Stafford165273.43,8986,22462.645,1097.22824.51442.33852,49689.9
Matt RyanMatt Ryan205272.04,8677,44365.455,7677.53474.71582.14102,70694.5
Peyton ManningPeyton Manning266270.56,1259,38065.371,9407.75395.72512.73031,95396.5
Tom BradyTom Brady301263.16,77810,59864.079,2047.55815.51911.85213,27297.3
Kurt WarnerKurt Warner124260.82,6664,07065.532,3447.92085.11283.12601,66993.7
Aaron RodgersAaron Rodgers197260.14,2856,58765.151,2457.84126.3891.44683,150103.9
Philip RiversPhilip Rivers244260.05,2778,13464.963,4407.84215.22092.64652,84295.2
Ben RoethlisbergerBen Roethlisberger233259.05,0507,83864.460,3487.73965.12012.65163,43894.0
Carson PalmerCarson Palmer182254.13,9416,30762.546,2477.32944.71873.03402,36487.9
Dan MarinoDan Marino242253.64,9678,35859.461,3617.34205.02523.02701,93086.4
Eli ManningEli Manning236241.64,8958,11960.357,0237.03664.52443.04112,87084.1
Brett FavreBrett Favre302237.96,30010,16962.071,8387.15085.03363.35253,48786.0
Dan FoutsDan Fouts181237.83,2975,60458.843,0407.72544.52424.33192,30480.2
Trent GreenTrent Green120237.32,2663,74060.628,4757.61624.31143.02591,62186.0
Warren MoonWarren Moon208237.13,9886,82358.449,3257.22914.32333.44583,41580.9
Russell WilsonRussell Wilson144235.72,8204,33565.133,9467.82676.2811.93942,572101.7
Andy DaltonAndy Dalton144234.52,9734,78262.233,7647.12184.61262.63021,92287.5
Joe FlaccoJoe Flacco176232.63,7446,06661.740,9316.72243.71442.43662,62384.1
Drew BledsoeDrew Bledsoe194230.03,8396,71757.244,6116.62513.72063.14673,13577.1
Jay CutlerJay Cutler153229.63,0484,92062.035,1337.12274.61603.33222,03585.3
Cam NewtonCam Newton140226.42,6134,34860.131,6987.31904.41182.73222,39485.8
Donovan McNabbDonovan McNabb167223.23,1705,37459.037,2766.92344.41172.24102,62685.6
Jim KellyJim Kelly160221.72,8744,77960.135,4677.42375.01753.73232,42784.4
Jim EverettJim Everett158220.52,8414,92357.734,8377.12034.11753.62571,88578.6
StatMuse has season-level data for passing yards per game going back to the 1932 season.

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