12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

who has the most interceptions in one game
Interpreted as:
Who has the most defensive interceptions in one regular-season game?
10/24/2010Hall10/7/2001O'Neal12/27/1998Lassiter9/29/1985Cherry9/24/1978Buchanon12/3/1973Anderson11/15/1964Brown10/4/1964Hunt12/16/1962Ply11/26/1961Norton12/4/1960Baker11/20/1960Norton9/18/1960Gonsoulin12/2/2018Adams10/22/2017Byard10/16/2011Coleman11/28/2010Quin11/22/2009Bodden10/4/2009Talib12/21/2008Hall12/9/2007Trufant12/2/2007Tatupu11/18/2007Rolle44444444444443333333333
Results may be incomplete. StatMuse has complete game-level data for interceptions going back to the 1960 season.

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