12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

who is the most interceptions in an nfl game
Interpreted as:
Who is the most defensive interceptions in an NFL regular-season game?
Results may be incomplete. StatMuse has complete game-level data for interceptions going back to the 1960 season.

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