12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

who is the most interceptions in an nfl game
Interpreted as:
Who is the most defensive interceptions in an NFL regular-season game?
10/24/2010 Hall 10/7/2001 O'Neal 12/27/1998 Lassiter 9/29/1985 Cherry 9/24/1978 Buchanon 12/3/1973 Anderson 11/15/1964 Brown 10/4/1964 Hunt 12/16/1962 Ply 11/26/1961 Norton 12/4/1960 Baker 11/20/1960 Norton 9/18/1960 Gonsoulin 9/11/2023 Whitehead 12/2/2018 Adams 10/22/2017 Byard 10/16/2011 Coleman 11/28/2010 Quin 11/22/2009 Bodden 10/4/2009 Talib 12/21/2008 Hall 12/9/2007 Trufant 12/2/2007 Tatupu 11/18/2007 Rolle 11/11/2007 Cromartie 9/24/2007 Bulluck 11/26/2006 Samuel 0 0.5 1.0 1.5 2 2.5 3 3.5 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3
Results may be incomplete. StatMuse has complete game-level data for interceptions going back to the 1960 season.

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