Between the 1970 and 1974 seasons, O.J. Simpson had the most rushing yards, with 5,609 yards.

who led the league in rushing yards from 1970 to 1974
SimpsonCsonkaBrownLittleBrockingtonHillHubbardJohnsonTaylorLanePodolakBoozerAndersonMorrisHamptonRigginsHarrisKellyEllisonJohnsonFuquaGarrison5.6k4.8k4.6k4.2k4.2k4.1k4.0k3.5k3.3k3.3k3.2k3.1k3.1k2.9k2.9k2.9k2.8k2.7k2.7k2.7k2.6k2.6k
NAMEGPRUSH YDSATTRUSH AVGRUSH YDS/GRUSH TDREC YDSRECTRGREC AVGREC YDS/GREC TD
O.J. SimpsonO.J. Simpson645,6091,1974.787.631758799.611.81
Larry CsonkaLarry Csonka684,7941,0174.770.533312437.34.61
Larry BrownLarry Brown634,5791,2113.872.7281,86016211.529.518
Floyd LittleFloyd Little704,1841,0823.959.8311,55014111.022.15
John BrockingtonJohn Brockington564,1591,0214.174.320783928.514.02
Calvin HillCalvin Hill604,0679624.267.8311,1271199.518.86
Marv HubbardMarv Hubbard693,9818324.857.720481706.97.01
Ron JohnsonRon Johnson533,4859503.765.8281,5331559.928.914
Altie TaylorAltie Taylor673,3118523.949.4201,3261399.519.86
MacArthur LaneMacArthur Lane683,2808403.948.2211,51814810.322.36
Ed PodolakEd Podolak633,1798343.850.5211,6552068.026.34
Emerson BoozerEmerson Boozer613,1427824.051.528811869.413.38
Donny AndersonDonny Anderson703,1418183.844.9271,54314610.622.09
Mercury MorrisMercury Morris582,8925125.649.9244113810.87.11
Dave HamptonDave Hampton552,8787353.952.315688719.712.53
John RigginsJohn Riggins472,8756904.261.217799998.117.05
Franco HarrisFranco Harris382,7595844.772.618449548.311.82
Leroy KellyLeroy Kelly542,7217963.450.4239478710.917.55
Willie EllisonWillie Ellison562,6706164.347.718591797.510.63
Essex JohnsonEssex Johnson602,6615764.644.4141,3099413.921.810
John FuquaJohn Fuqua592,5946104.344.0191,0861139.618.43
Walt GarrisonWalt Garrison652,5896384.139.8221,5171589.623.39
Carl GarrettCarl Garrett572,5456713.844.6161,31511711.223.12
Ken WillardKen Willard632,5306753.740.2167801087.212.47
Jess PhillipsJess Phillips692,4946773.736.17523965.47.62
StatMuse has season-level data for rushing yards going back to the 1932 season.

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