Davante Adams and Mike Williams are are tied for targeted the most times in a Week-5 game this season, with 16 targets on October 10.

2021 week 5 highest "target share"
Interpreted as:
2021 week 5 highest "target by a player share this season"
10/10/2021Adams10/10/2021Williams10/7/2021Woods10/11/2021Andrews10/10/2021Toney10/10/2021Hill10/10/2021Hardman10/10/2021Godwin10/10/2021Sutton10/10/2021McLaurin10/11/2021Brown10/10/2021Pitts10/10/2021Gaskin10/10/2021Chase10/10/2021Kelce10/7/2021Lockett10/7/2021Kupp10/10/2021Patterson10/10/2021Patrick10/10/2021Smith10/10/2021Seals-Jones10/10/2021Allen10/10/2021Hopkins1616141313131211111110101010101010999999
StatMuse has game-level data for targets going back to the 1999 season.