The San Francisco 49ers had a record of 25-12 against the AFC in the regular-season and playoffs at home between the 1995 and 2012 seasons.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/17/1995 | 1-0 |  SF | vs |  NE | W 28-3 | 1.000 | 4 | 21 | 363 | 302 | 38.5 | 100.0 |
| 2 | | 49ers | 12/3/1995 | 1-0 | SF | vs |  BUF | W 27-17 | 1.000 | 3 | 18 | 323 | 275 | 31.3 | 50.0 |
| 3 | | 49ers | 10/20/1996 | 1-0 | SF | vs |  CIN | W 28-21 | 1.000 | 4 | 20 | 418 | 345 | 38.5 | 50.0 |
| 4 | | 49ers | 11/17/1996 | 1-0 | SF | vs |  BAL | W 38-20 | 1.000 | 5 | 22 | 372 | 268 | 41.7 | 100.0 |
| 5 | | 49ers | 11/23/1997 | 1-0 | SF | vs |  SD | W 17-10 | 1.000 | 2 | 19 | 339 | 203 | 30.8 | |
| 6 | | 49ers | 12/15/1997 | 1-0 | SF | vs |  DEN | W 34-17 | 1.000 | 4 | 18 | 323 | 237 | 38.5 | |
| 7 | | 49ers | 9/6/1998 | 1-0 | SF | vs |  NYJ | W 36-30 | 1.000 | 5 | 26 | 557 | 465 | 33.3 | 100.0 |
| 8 | | 49ers | 10/18/1998 | 1-0 | SF | vs |  IND | W 34-31 | 1.000 | 4 | 36 | 448 | 336 | 54.5 | |
| 9 | | 49ers | 10/3/1999 | 1-0 | SF | vs |  TEN | W 24-22 | 1.000 | 3 | 17 | 329 | 392 | 38.5 | |
| 10 | | 49ers | 11/7/1999 | 0-1 | SF | vs |  PIT | L 6-27 | .000 | 0 | 16 | 313 | 271 | 21.4 | 0.0 |
| 11 | | 49ers | 10/8/2000 | 0-1 | SF | vs |  OAK | L 28-34 | .000 | 4 | 28 | 472 | 471 | 60.0 | 0.0 |
| 12 | | 49ers | 11/12/2000 | 1-0 | SF | vs |  KC | W 21-7 | 1.000 | 3 | 25 | 389 | 294 | 50.0 | |
| 13 | | 49ers | 12/2/2001 | 1-0 | SF | vs | BUF | W 35-0 | 1.000 | 5 | 26 | 409 | 191 | 66.7 | 0.0 |
| 14 | | 49ers | 12/16/2001 | 1-0 | SF | vs |  MIA | W 21-0 | 1.000 | 3 | 21 | 285 | 174 | 50.0 | 50.0 |
| 15 | | 49ers | 9/15/2002 | 0-1 | SF | vs | DEN | L 14-24 | .000 | 2 | 18 | 261 | 299 | 61.5 | |
| 16 | | 49ers | 11/10/2002 | 1-0 | SF | vs | KC | W 17-13 | 1.000 | 2 | 22 | 323 | 256 | 61.1 | 100.0 |
| 17 | | 49ers | 9/21/2003 | 0-1 | SF | vs |  CLE | L 12-13 | .000 | 0 | 15 | 265 | 251 | 33.3 | 0.0 |
| 18 | | 49ers | 11/17/2003 | 1-0 | SF | vs | PIT | W 30-14 | 1.000 | 3 | 17 | 423 | 349 | 33.3 | 0.0 |
| 19 | | 49ers | 11/28/2004 | 0-1 | SF | vs | MIA | L 17-24 | .000 | 2 | 16 | 224 | 200 | 31.3 | |
| 20 | | 49ers | 12/26/2004 | 0-1 | SF | vs | BUF | L 7-41 | .000 | 1 | 12 | 189 | 441 | 30.0 | 100.0 |
| 21 | | 49ers | 10/9/2005 | 0-1 | SF | vs | IND | L 3-28 | .000 | 0 | 12 | 177 | 365 | 21.4 | 100.0 |
| 22 | | 49ers | 1/1/2006 | 1-0 | SF | vs |  HOU | W 20-17 | 1.000 | 2 | 19 | 324 | 284 | 36.8 | |
| 23 | | 49ers | 10/8/2006 | 1-0 | SF | vs | OAK | W 34-20 | 1.000 | 4 | 18 | 330 | 370 | 45.5 | 0.0 |
| 24 | | 49ers | 10/15/2006 | 0-1 | SF | vs | SD | L 19-48 | .000 | 2 | 15 | 274 | 421 | 36.4 | 0.0 |
| 25 | | 49ers | 10/7/2007 | 0-1 | SF | vs | BAL | L 7-9 | .000 | 1 | 6 | 163 | 315 | 25.0 | |
| Average | .676 | 2.8 | 19.5 | 340.0 | 307.4 | 40.6 | 1.8 | ||||||||
| Total | 25-12 | .676 | 102 | 723 | 12,579 | 11,373 | 40.6 | 43.2 | |||||||
More 49ers Stats
Team Rankings
PPG
22.9
13th
OPP PPG
25.6
29th
RUSH YDS/G
127.2
12th
PASS YDS/G
260.2
4th
Cardinals 
NO 
JAX 
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NFL Fantasy 2024
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NFL 2024 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
 Lions | 15 | 2 | 0 | .882 |
 Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
 Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
 Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
CAR 
DAL 
NYJ 
