The Buffalo Bills are 11-9-1 against the spread as favorites against the NFC since January 26, 2020.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/27/2020 | 1-0 |  BUF | -124 | vs |  LAR | +105 | W 35-32 | -1.5 | +1.5 (Y) | 46.5 | +20.5 (O) | 5 | 23 | 375 | 478 | 50.0 | 100.0 |
| 2 | | Bills | 9/26/2021 | 1-0 | BUF | -346 | vs |  WAS | +270 | W 43-21 | -7 | +15 (Y) | 45.5 | +18.5 (O) | 5 | 29 | 481 | 290 | 60.0 | 0.0 |
| 3 | | Bills | 11/25/2021 | 1-0 | BUF | -302 | @ |  NO | +239 | W 31-6 | -7 | +18 (Y) | 45 | -8 (U) | 4 | 21 | 361 | 190 | 61.5 | 100.0 |
| 4 | | Bills | 12/19/2021 | 1-0 | BUF | -834 | vs |  CAR | +557 | W 31-14 | -14.5 | +2.5 (Y) | 43 | +2 (O) | 4 | 21 | 312 | 275 | 42.9 | 100.0 |
| 5 | | Bills | 1/2/2022 | 0-0-1 | BUF | -947 | vs |  ATL | +625 | W 29-15 | -14 | 0 (P) | 46 | -2 (U) | 4 | 28 | 351 | 265 | 58.3 | 100.0 |
| 6 | | Bills | 9/8/2022 | 1-0 | BUF | -131 | @ | LAR | +110 | W 31-10 | -2.5 | +18.5 (Y) | 52 | -11 (U) | 4 | 23 | 413 | 243 | 90.0 | |
| 7 | | Bills | 10/30/2022 | 0-1 | BUF | -502 | vs |  GB | +381 | W 27-17 | -10.5 | -0.5 (N) | 47 | -3 (U) | 3 | 20 | 369 | 398 | 28.6 | |
| 8 | | Bills | 11/13/2022 | 0-1 | BUF | -274 | vs |  MIN | +222 | L 30-33 | -6.5 | -9.5 (N) | 46.5 | +16.5 (O) | 3 | 29 | 486 | 481 | 53.8 | 0.0 |
| 9 | | Bills | 11/24/2022 | 0-1 | BUF | -433 | @ |  DET | +338 | W 28-25 | -9.5 | -6.5 (N) | 54.5 | -1.5 (U) | 3 | 28 | 401 | 326 | 58.3 | |
| 10 | | Bills | 12/24/2022 | 1-0 | BUF | -398 | @ |  CHI | +312 | W 35-13 | -8 | +14 (Y) | 40.5 | +7.5 (O) | 5 | 20 | 426 | 209 | 54.5 | 100.0 |
| 11 | | Bills | 9/24/2023 | 1-0 | BUF | -235 | @ |  WAS | +194 | W 37-3 | -5 | +29 (Y) | 44 | -4 (U) | 4 | 20 | 386 | 230 | 60.0 | 0.0 |
| 12 | | Bills | 10/15/2023 | 0-1 | BUF | -1216 | vs |  NYG | +750 | W 14-9 | -15 | -10 (N) | 43.5 | -20.5 (U) | 2 | 22 | 297 | 317 | 50.0 | |
| 13 | | Bills | 10/26/2023 | 0-1 | BUF | -516 | vs |  TB | +384 | W 24-18 | -10 | -4 (N) | 43 | -1 (U) | 3 | 25 | 427 | 302 | 53.8 | 0.0 |
| 14 | | Bills | 12/17/2023 | 1-0 | BUF | -139 | vs |  DAL | +117 | W 31-10 | -2.5 | +18.5 (Y) | 49 | -8 (U) | 4 | 28 | 351 | 195 | 55.6 | |
| 15 | | Bills | 9/8/2024 | 0-1 | BUF | -308 | vs |  ARI | +246 | W 34-28 | -6.5 | -0.5 (N) | 45.5 | +16.5 (O) | 4 | 23 | 352 | 270 | 33.3 | 100.0 |
| 16 | | Bills | 10/27/2024 | 1-0 | BUF | -163 | @ |  SEA | +137 | W 31-10 | -3 | +18 (Y) | 45.5 | -4.5 (U) | 4 | 29 | 445 | 233 | 53.3 | 100.0 |
| 17 | | Bills | 12/1/2024 | 1-0 | BUF | -330 | vs |  SF | +265 | W 35-10 | -6.5 | +18.5 (Y) | 45.5 | -0.5 (U) | 5 | 20 | 372 | 239 | 50.0 | 100.0 |
| 18 | | Bills | 12/8/2024 | 0-1 | BUF | -191 | @ | LAR | +158 | L 42-44 | -3.5 | -5.5 (N) | 50 | +36 (O) | 6 | 25 | 445 | 457 | 55.6 | |
| 19 | | Bills | 9/28/2025 | 0-1 | BUF | -1389 | vs | NO | +833 | W 31-19 | -14.5 | -2.5 (N) | 48.5 | +1.5 (O) | 4 | 20 | 356 | 298 | 30.0 | 0.0 |
| 20 | | Bills | 10/13/2025 | 0-1 | BUF | -203 | @ | ATL | +169 | L 14-24 | -3.5 | -13.5 (N) | 49.5 | -11.5 (U) | 2 | 17 | 291 | 443 | 22.2 | 0.0 |
| 21 | | Bills | 10/26/2025 | 1-0 | BUF | -398 | @ | CAR | +314 | W 40-9 | -7.5 | +23.5 (Y) | 47.5 | +1.5 (O) | 5 | 23 | 410 | 244 | 58.3 | |
| Average | 2.6 | 4.0 | 23.5 | 386.0 | 304.0 | 52.5 | 4.3 | |||||||||||||
| Total | 11-9-1 | 83 | 494 | 8,107 | 6,383 | 52.5 | 60.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More Bills Stats
Team Rankings
PPG
29.6
4th
OPP PPG
20.9
9th
RUSH YDS/G
164.4
1st
PASS YDS/G
230.6
15th
Patriots
Dolphins
Jets
KC
HOU
PIT
Bengals
Colts
Jaguars
Broncos
Chargers
Eagles
LV
