The Buffalo Bills are 2-1 against the spread as favorites against the NFC South on the road since January 26, 2020.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 11/25/2021 | 1-0 |  BUF | -302 | @ |  NO | +239 | W 31-6 | -7 | +18 (Y) | 45 | -8 (U) | 4 | 21 | 361 | 190 | 61.5 | 100.0 |
| 2 | | Bills | 10/13/2025 | 0-1 | BUF | -203 | @ |  ATL | +169 | L 14-24 | -3.5 | -13.5 (N) | 49.5 | -11.5 (U) | 2 | 17 | 291 | 443 | 22.2 | 0.0 |
| 3 | | Bills | 10/26/2025 | 1-0 | BUF | -398 | @ |  CAR | +314 | W 40-9 | -7.5 | +23.5 (Y) | 47.5 | +1.5 (O) | 5 | 23 | 410 | 244 | 58.3 | |
| Average | 22.2 | 3.7 | 20.3 | 354.0 | 292.3 | 50.0 | 25.0 | |||||||||||||
| Total | 2-1 | 11 | 61 | 1,062 | 877 | 50.0 | 50.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More Bills Stats
Team Rankings
PPG
29.6
4th
OPP PPG
20.9
9th
RUSH YDS/G
164.4
1st
PASS YDS/G
230.6
15th
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