Emmitt Smith has the highest career 100 * rush attempts + rushing touchdowns per rush attempt + rush attempts by a running back, with 445,309.04.

highest career 100 * rush + td / rush + att by a rb with 25+ or more rush + td
Interpreted as:
highest career 100 * rush + rushing td / rush + rushing att by a rb with 25+ or more rush + rushing td

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