The Pittsburgh Steelers have the best passer rating by a team in a loss with 300+ passing yards and 25+ passing attempts, with a 150.4 rating against the Falcons on October 22, 2006.

highest passer rating in a loss with at least 300 yards and 25 pass attempts thrown all-time
Interpreted as:
highest passer rating in a regular-season loss with at least 300 yards and 25 or more pass attempts thrown all-time

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