James Cook III has gotten 24 total touchdowns against the AFC in his career.

	NAME	DATE	TD	TM		OPP	RUSH TD	REC TD	RET TD	FGM	XPM	XP2	SFTY	PTS
1	James Cook III J. Cook III	9/19/2022	0	BUF	vs	TEN	0	0	0	0	0	0	0	0
2	James Cook III J. Cook III	9/25/2022	0	BUF	@	MIA	0	0	0	0	0	0	0	0
3	James Cook III J. Cook III	10/2/2022	0	BUF	@	BAL	0	0	0	0	0	0	0	0
4	James Cook III J. Cook III	10/9/2022	1	BUF	vs	PIT	1	0	0	0	0	0	0	6
5	James Cook III J. Cook III	10/16/2022	0	BUF	@	KC	0	0	0	0	0	0	0	0
6	James Cook III J. Cook III	11/6/2022	0	BUF	@	NYJ	0	0	0	0	0	0	0	0
7	James Cook III J. Cook III	11/20/2022	0	BUF	vs	CLE	0	0	0	0	0	0	0	0
8	James Cook III J. Cook III	12/1/2022	0	BUF	@	NE	0	0	0	0	0	0	0	0
9	James Cook III J. Cook III	12/11/2022	0	BUF	vs	NYJ	0	0	0	0	0	0	0	0
10	James Cook III J. Cook III	12/17/2022	1	BUF	vs	MIA	0	1	0	0	0	0	0	6
11	James Cook III J. Cook III	1/8/2023	0	BUF	vs	NE	0	0	0	0	0	0	0	0
12	James Cook III J. Cook III	9/11/2023	0	BUF	@	NYJ	0	0	0	0	0	0	0	0
13	James Cook III J. Cook III	9/17/2023	0	BUF	vs	LV	0	0	0	0	0	0	0	0
14	James Cook III J. Cook III	10/1/2023	1	BUF	vs	MIA	1	0	0	0	0	0	0	6
15	James Cook III J. Cook III	10/8/2023	0	BUF	vs	JAX	0	0	0	0	0	0	0	0
16	James Cook III J. Cook III	10/22/2023	1	BUF	@	NE	0	1	0	0	0	0	0	6
17	James Cook III J. Cook III	11/5/2023	0	BUF	@	CIN	0	0	0	0	0	0	0	0
18	James Cook III J. Cook III	11/13/2023	0	BUF	vs	DEN	0	0	0	0	0	0	0	0
19	James Cook III J. Cook III	11/19/2023	1	BUF	vs	NYJ	0	1	0	0	0	0	0	6
20	James Cook III J. Cook III	12/10/2023	1	BUF	@	KC	0	1	0	0	0	0	0	6
21	James Cook III J. Cook III	12/23/2023	0	BUF	@	LAC	0	0	0	0	0	0	0	0
22	James Cook III J. Cook III	12/31/2023	0	BUF	vs	NE	0	0	0	0	0	0	0	0
23	James Cook III J. Cook III	1/7/2024	0	BUF	@	MIA	0	0	0	0	0	0	0	0
24	James Cook III J. Cook III	9/12/2024	3	BUF	@	MIA	2	1	0	0	0	0	0	18
25	James Cook III J. Cook III	9/23/2024	1	BUF	vs	JAX	1	0	0	0	0	0	0	6
	Average		0.6				0.4	0.1	0.0	0.0	0.0	0.0	0.0	3.3
	Total		24				18	6	0	0	0	0	0	144

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StatMuse has game-level data for touchdowns going back to the 1950 season.

More Bills Stats

Team Leaders

PASS

3,083

Allen

RUSH

1,308

Cook

REC

585

Shakir

Team Rankings

PPG

28.9

5th

OPP PPG

22.5

14th

RUSH YDS/G

157.8

1st

PASS YDS/G

241.3

12th

2025 Division Standings

TEAM	W	L	PCT
Patriots	11	2	.846
Bills	9	4	.692
Dolphins	6	7	.462
Jets	3	10	.231

Schedule

DATE	MATCHUP			TIME (ET)
Sun 12/14	BUF	@	NE	1:00 PM
Sun 12/21	BUF	@	CLE	1:00 PM
Sun 12/28	PHI	@	BUF	4:25 PM
Sun 1/4	NYJ	@	BUF	1:00 PM

Last Game

Bengals

4 - 9

Final

Bills

9 - 4

Sun 7 Dec 2025

NFL 2025 Leaders

Pass Yards Leaders

3,637

Prescott

3,412

Maye

3,398

Mahomes

Rush Yards Leaders

1,356

Taylor

1,308

Cook

1,126

Achane

Rec Yards Leaders

1,428

Smith-Njigba

1,186

Nacua

1,179

Pickens

Pass TD Leaders

35

Stafford

26

Prescott

26

Goff

Rush TD Leaders

16

Taylor

13

Gibbs

12

Jacobs

Rec TD Leaders

14

Adams

9

Smith-Njigba

9

St. Brown

QB Rating Leaders

113.1

Stafford

111.9

Maye

110.2

Goff

Sack Leaders

20.0

Garrett

13.0

Burns

12.5

Parsons

NFL 2025 Rankings

PPG Rankings

30.3

29.8

29.3

29.2

28.9

Opp PPG Rankings

16.0

17.4

17.5

18.1

18.5

19.0

Total Yards Rankings

394.9

383.7

378.7

373.2

369.7

368.5

Rush Yards Rankings

157.8

152.6

142.9

136.5

135.8

130.9

Pass Yards Rankings

287.4

263.4

263.0

261.4

258.0

256.7

Sack Leaders

55.0

44.0

43.0

41.0

37.0

36.0

NFL Fantasy 2025

Fantasy RB Rankings

274

Taylor

249.6

Gibbs

243.5

McCaffrey

Fantasy WR Rankings

198.4

Smith-Njigba

167.9

Pickens

165.9

Nacua

Fantasy TE Rankings

141.7

McBride

104.8

Kelce

100.7

Warren

Fantasy K Rankings

158

Myers

144

Aubrey

124

Fairbairn

NFL 2025 Betting

Best Record ATS

10-3

9-4

8-4-1

8-5

Worst Record ATS

4-9

5-8

NFL 2025 Division Standings

AFC East	W	L	T	PCT
Patriots	11	2	0	.846
Bills	9	4	0	.692
AFC North	W	L	T	PCT
Steelers	7	6	0	.538
Ravens	6	7	0	.462
AFC South	W	L	T	PCT
Jaguars	9	4	0	.692
Texans	8	5	0	.615
AFC West	W	L	T	PCT
Broncos	11	2	0	.846
Chargers	8	4	0	.667

NFC East	W	L	T	PCT
Eagles	8	4	0	.667
Cowboys	6	6	1	.500
NFC North	W	L	T	PCT
Packers	9	3	1	.731
Bears	9	4	0	.692
NFC South	W	L	T	PCT
Buccaneers	7	6	0	.538
Panthers	7	6	0	.538
NFC West	W	L	T	PCT
Rams	10	3	0	.769
Seahawks	10	3	0	.769