Peyton Manning has the most interceptions by a rookie quarterback, with 28 interceptions in 1998.

most interceptions by rookie qb all-time
Interpreted as:
most passing interceptions by rookie qb all-time
1998Manning1976Zorn1970Bradshaw1962Hadl1950Rote1979Komlo2017Kizer1978DeBerg1961Snead1954McHan2013Smith1971Pastorini1966Johnson2009Sanchez2009Stafford1970Shaw1947LeForce2001Weinke1995Collins1967Nix1955Shaw2012Luck2009Freeman2827242424232222222221212120202020191919191818
NAMESEASONTMGPINTCMPATTPCTYDSAVGYDS/GTDTD%INT%SCKSCKYRATE
Peyton ManningPeyton Manning1998INDIND162832657556.73,7396.5233.7264.54.92210971.2
Jim ZornJim Zorn1976SEASEA142720843947.42,5715.9183.6122.76.22519649.5
Terry BradshawTerry Bradshaw1970PITPIT13248321838.11,4106.5108.562.811.02524230.4
John HadlJohn Hadl1962SDSD142410726041.21,6326.3116.6155.89.243.3
Tobin RoteTobin Rote1950GBGB12248322437.11,2315.5102.673.110.726.7
Jeff KomloJeff Komlo1979DETDET162318336849.72,2386.1139.9113.06.34036152.8
DeShone KizerDeShone Kizer2017CLECLE152225547653.62,8946.1192.9112.34.63822660.5
Steve DeBergSteve DeBerg1978SFSF122213730245.41,5705.2130.882.67.31715640.0
Norm SneadNorm Snead1961WASWAS142217237545.92,3376.2166.9112.95.951.6
Lamar McHanLamar McHan1954CHCCHC122210525541.21,4755.8122.962.48.632.4
Geno SmithGeno Smith2013NYJNYJ162124744355.83,0466.9190.4122.74.74331566.5
Dan PastoriniDan Pastorini1971HOUHOU142112727047.01,7026.3121.672.67.82015243.8
Randy JohnsonRandy Johnson1966ATLATL142112929543.71,7956.1128.2124.17.147.8
Mark SanchezMark Sanchez2009NYJNYJ152019636453.82,4446.7162.9123.35.52619563.0
Matthew StaffordMatthew Stafford2009DETDET102020137753.32,2676.0226.7133.45.32416961.0
Dennis ShawDennis Shaw1970BUFBUF142017832155.52,5077.8179.1103.16.24138765.3
Clyde LeForceClyde LeForce1947DETDET9209417553.71,3847.9153.8137.411.465.0
Chris WeinkeChris Weinke2001CARCAR151929354054.32,9315.4195.4112.03.52617762.0
Kerry CollinsKerry Collins1995CARCAR151921443349.42,7176.3181.1143.24.42415061.9
Kent NixKent Nix1967PITPIT121913626850.71,5875.9132.383.07.149.5
George ShawGeorge Shaw1955BALBAL121911923750.21,5866.7132.2104.28.052.5
Andrew LuckAndrew Luck2012INDIND161833962754.14,3747.0273.4233.72.94124676.5
Josh FreemanJosh Freeman2009TBTB101815829054.51,8556.4185.5103.46.22010259.8
Carson PalmerCarson Palmer2004CINCIN131826343260.92,8976.7222.8184.24.22517877.3
Troy AikmanTroy Aikman1989DALDAL111815529352.91,7496.0159.093.16.11915555.7
StatMuse has season-level data for intercepted passes going back to the 1932 season.