Sam Cunningham had the most games by a Patriots running back when he had 100 or more (YDS+YDS) and had more than 0 (2+YDS+TD), with 52 games.

most games by a patriots running back with 100 or more rushing+ yards and 2 + rushing+ tds
Interpreted as:
most regular-season games by a patriots running back with 100 or more rushing+ rushing yards and 2 + rushing+ rushing tds

See Trending NFL Searches