Between September 1, 2017 and October 29, 2017, DeAndre Hopkins had the most games by a wide receiver with 12+ targets, with 4 games.

most games of 12 targets by a wr from 9-1-2017 to 10-29-2017
Interpreted as:
most regular-season games of 12 or more targets by a wr from 9-1-2017 to 10-29-2017

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