O.J. Simpson had the most games with 200+ rushing yards and when he had more than 0 (2*TD), with 6 games.

most games with 200 rushing yards and 2* rushing touchdowns
Interpreted as:
most regular-season games with 200 or more rushing yards and 2* rushing touchdowns by a player
SimpsonHenryPetersonBarberTomlinsonAjayiCharlesLewisFaulkDillonDavisSandersBellBrownBellTurnerParkerJohnsonPortisWilliamsJamesDickersonRiggs65544333333333222222222
NAMEGPRUSH TDRUSH YDS2*TDATTRUSH AVGRUSH YDS/GREC YDSRECTRGREC AVGREC YDS/GREC TD
O.J. SimpsonO.J. Simpson681,372161668.3228.71226.02.00
Derrick HenryDerrick Henry5131,126261318.6225.2594714.811.80
Adrian PetersonAdrian Peterson591,145181219.5229.0515910.210.20
Tiki BarberTiki Barber47863141048.3215.811815187.929.50
LaDainian TomlinsonLaDainian Tomlinson48880161217.3220.010926394.227.30
Jay AjayiJay Ajayi346248857.3208.08342.72.70
Jamaal CharlesJamaal Charles347188809.0239.3628127.820.70
Jamal LewisJamal Lewis3571610799.1238.721367.07.00
Marshall FaulkMarshall Faulk3563010877.2210.016917219.956.31
Corey DillonCorey Dillon3774014967.7246.7302015.010.00
Terrell DavisTerrell Davis336306996.4210.04276.014.00
Barry SandersBarry Sanders3865116719.2217.04876.916.01
Greg BellGreg Bell346378817.9212.31635.35.31
Jim BrownJim Brown3769214828.4230.752317.317.30
Le'Veon BellLe'Veon Bell244408716.2220.0806913.340.00
Michael TurnerMichael Turner234286479.1214.06116.03.00
Willie ParkerWillie Parker234366548.1218.012236.06.00
Larry JohnsonLarry Johnson2541210626.6206.027339.013.50
Clinton PortisClinton Portis2744614469.7223.0544513.527.00
Ricky WilliamsRicky Williams244448587.7222.07491.83.50
Edgerrin JamesEdgerrin James244238616.9211.5202210.010.00
Eric DickersonEric Dickerson244228577.4211.038219.019.00
Gerald RiggsGerald Riggs234236646.6211.5000.00
George RogersGeorge Rogers234126587.1206.0000.00
Earl CampbellEarl Campbell234056567.2202.5-11-1.0-0.50
StatMuse has game-level data for rushing touchdowns and rushing yards going back to the 1960 season.

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