Tom Brady has the most passing yards in a game on Mondays, with 517 yards against the Dolphins on September 12, 2011.

most monday night football passing yards, single game
Interpreted as:
most monday night football passing yards by a player, single regular-season game
9/12/2011Brady11/19/2018Mahomes12/11/1989Montana11/29/2004Bulger11/17/1975Anderson11/18/1974Johnson10/11/2021Jackson10/5/1998Cunningham9/4/2000Warner11/17/1986Montana9/25/2000Manning9/13/2021Carr12/20/1982Fouts12/13/2004Volek10/15/2018Rodgers12/18/1995Young11/23/1998Bledsoe11/24/2014Brees10/27/1986Schroeder9/12/2011Henne12/20/1982Anderson12/6/2004Hasselbeck11/19/2018Goff517478458448447445442442441441440435435426425425423420420416416414413
NAMEDATETMOPPYDSCMPATTPCTAVGTDTD%INTINT%SCKSCKYRATE
Tom BradyTom Brady9/12/2011NENE@MIAMIA517324866.710.848.312.111121.6
Patrick MahomesPatrick Mahomes11/19/2018KCKC@LARLAR478334671.710.4613.036.5330117.6
Joe MontanaJoe Montana12/11/1989SFSF@RAMRAM458304271.410.937.124.8219111.0
Marc BulgerMarc Bulger11/29/2004STLSTL@GBGB448355366.08.523.811.944397.1
Ken AndersonKen Anderson11/17/1975CINCINvsBUFBUF447304665.29.724.300.0111.4
Charley JohnsonCharley Johnson11/18/1974DENDENvsKCKC445284266.710.624.824.897.8
Lamar JacksonLamar Jackson10/11/2021BALBALvsINDIND442374386.010.349.300.025140.5
Randall CunninghamRandall Cunningham10/5/1998MINMIN@GBGB442203262.513.8412.500.000145.8
Kurt WarnerKurt Warner9/4/2000STLSTLvsDENDEN441253571.412.638.638.628106.5
Joe MontanaJoe Montana11/17/1986SFSF@WASWAS441336055.07.400.035.032357.7
Peyton ManningPeyton Manning9/25/2000INDINDvsJAXJAX440233663.912.2411.100.000143.3
Derek CarrDerek Carr9/13/2021LVLVvsBALBAL435345660.77.823.611.832689.5
Dan FoutsDan Fouts12/20/1982SDSDvsCINCIN435254062.510.912.525.021587.0
Billy VolekBilly Volek12/13/2004TENTENvsKCKC426294367.49.949.300.0547130.6
Aaron RodgersAaron Rodgers10/15/2018GBGBvsSFSF425254654.39.224.300.0320100.4
Steve YoungSteve Young12/18/1995SFSFvsMINMIN425304961.28.736.124.11092.6
Drew BledsoeDrew Bledsoe11/23/1998NENEvsMIAMIA423285451.97.823.723.71974.8
Drew BreesDrew Brees11/24/2014NONOvsBALBAL420354577.89.336.712.2421118.5
Jay SchroederJay Schroeder10/27/1986WASWAS@NYGNYG420224055.010.512.525.044279.2
Chad HenneChad Henne9/12/2011MIAMIAvsNENE416304961.28.524.112.042693.6
Ken AndersonKen Anderson12/20/1982CINCIN@SDSD416405671.47.423.611.831997.0
Matt HasselbeckMatt Hasselbeck12/6/2004SEASEAvsDALDAL414284070.010.437.500.0216128.5
Jared GoffJared Goff11/19/2018LARLARvsKCKC413314963.38.448.200.0534117.1
Drew BreesDrew Brees9/30/2013NONOvsMIAMIA413303976.910.6410.300.0216144.5
Pete BeathardPete Beathard9/9/1968HOUHOUvsKCKC413234847.98.624.236.365.7
Results may be incomplete. StatMuse has complete game-level data for passing yards going back to the 1950 season.