7 players are tied for the most passing touchdowns + rushing touchdowns + receiving touchdowns + punt-return touchdowns in a game, with 7. The first three are Drew Brees on November 1, 2015, Nick Foles on November 3, 2013 and Peyton Manning on September 5, 2013.

most passing tds + rushing tds + receiving tds + punt ret tds in a game
Interpreted as:
most passing tds + rushing tds + receiving tds + punt ret tds by a player in a regular-season game

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