Barry Sanders has rushed for the most career yards versus the Bears, with 1,846 yards.

most rushing yards against the bears all-time
Interpreted as:
most rushing yards by a player against the bears all-time
SandersPetersonTaylorGreenForemanSmithBrockingtonOsbornBrownWilderDunnGrantPietrosanteAllenTaylorLevensStewartBennettSmithGoreBassAlstottBussey1.8k1.7k1.1k1.1k937891879809772715681672672651630622618603600587587556551
NAMEGPRUSH YDSATTYPCRUSH YDS/GRUSH TDREC YDSRECTRGAVGREC YDS/GREC TD
Barry SandersBarry Sanders191,8463685.097.2123323310.117.51
Adrian PetersonAdrian Peterson171,7493584.9102.91619632516.111.50
Jim TaylorJim Taylor141,1262414.780.412204326.414.60
Ahman GreenAhman Green141,0812334.677.2630137488.121.50
Chuck ForemanChuck Foreman149372393.966.98365409.126.10
Robert SmithRobert Smith138911555.768.551111269.38.51
John BrockingtonJohn Brockington138792333.867.67201219.615.50
Dave OsbornDave Osborn218092034.038.53247279.111.81
Bill BrownBill Brown257721954.030.943843610.715.42
James WilderJames Wilder167151744.144.71265357.616.60
Warrick DunnWarrick Dunn136811684.152.4131442507.524.21
Ryan GrantRyan Grant96721335.174.758911138.19.91
Nick PietrosanteNick Pietrosante136721534.451.73146159.711.20
Terry AllenTerry Allen96511394.772.351191319.213.20
Altie TaylorAltie Taylor146301713.745.05148246.210.60
Dorsey LevensDorsey Levens166221374.538.9220230206.712.62
James StewartJames Stewart76181514.188.3624025239.634.32
Edgar BennettEdgar Bennett106031643.760.33161198.516.13
J.D. SmithJ.D. Smith86001264.875.062054.02.50
Frank GoreFrank Gore75871105.383.926410136.49.10
Dick BassDick Bass145871354.341.96138168.69.90
Mike AlstottMike Alstott165561503.734.8614329284.98.91
Dexter BusseyDexter Bussey195511503.729.023312911.417.41
Herschel WalkerHerschel Walker125361373.944.72244298.420.31
Tommy MasonTommy Mason125131303.942.832482211.320.70
StatMuse has game-level data for rushing yards going back to the 1960 season.