Jim Brown had the most touchdowns per game played * 250 when playing 10+ games, with 266.95.

most touchdowns per game * 250 in career with at least 10 games played
Interpreted as:
most touchdowns per game * 250 by a player in career with at least 10 games played
BrownKamaraTomlinsonVan BurenAlexanderHutsonGurleyMcCaffreyFosterDavisHolmesSayersWilliamsElliottJonesCookSimsMooreGibsonHuntHillSimsHenry266.9242.3238.2231.9227.6226.3224.4213212.5208.3208205.9204.5203.9203.4201.1198.3197.6197.4196.4196.2195.8195.8
NAMEGPTD/GP*250TDRUSH TDREC TDRET TDFGMXPMXP2SFTYPTSPPG
Jim BrownJim Brown118266.91261062000007566.4
Alvin KamaraAlvin Kamara65242.3634418100403865.9
LaDainian TomlinsonLaDainian Tomlinson170238.216214517000009725.7
Steve Van BurenSteve Van Buren83231.97769350204645.6
Shaun AlexanderShaun Alexander123227.611210012000006725.5
Don HutsonDon Hutson116226.31053993717208237.1
Todd GurleyTodd Gurley88224.4796712000404825.5
Christian McCaffreyChristian McCaffrey54213463016000102785.1
Arian FosterArian Foster80212.5685414000104105.1
Terrell DavisTerrell Davis78208.365605000303965.1
Priest HolmesPriest Holmes11320894868000105665.0
Gale SayersGale Sayers68205.95639980003364.9
Karlos WilliamsKarlos Williams11204.597200000544.9
Ezekiel ElliottEzekiel Elliott76203.9625111000103744.9
Aaron JonesAaron Jones59203.448399000002884.9
Dalvin CookDalvin Cook46201.137343000302285.0
David SimsDavid Sims29198.32319400001384.8
Lenny MooreLenny Moore143197.6113634820006784.7
Antonio GibsonAntonio Gibson19197.41514100000904.7
Kareem HuntKareem Hunt56196.4442816000102664.8
Tyreek HillTyreek Hill79196.262651500003724.7
Billy SimsBilly Sims60195.84742500002824.7
Derrick HenryDerrick Henry83195.865623000203944.7
Emmitt SmithEmmitt Smith226193.617516411000101,0524.7
Marshall FaulkMarshall Faulk176193.213610036000708304.7
StatMuse has season-level data for touchdowns going back to the 1921 season.

Try also: