Drew Brees averaged the most passing yards per game by a quarterback when playing >100 games, with 280.0 per game.

most yards per game by quarterbacks all-time with over 100 games played
Interpreted as:
most passing yards per game by quarterbacks all-time with over 100 games played
BreesStaffordRyanManningBradyCousinsWarnerRiversRodgersRoethlisbergerPalmerMarinoCarrManningFavreFoutsGreenMoonWilsonTannehillFlaccoDaltonCulpepper280.0274.9272.2270.5264.5262.1260.8260.0259.6258.8254.1253.6249.3241.6237.9237.8237.3237.1235.9233.6232.6231.5230.0
NAMEGPYDS/GCMPATTPCTYDSAVGTDTD%INTINT%SCKSCKYRATE
Drew BreesDrew Brees287280.07,14210,55167.780,3587.65715.42432.34202,99198.7
Matthew StaffordMatthew Stafford172274.94,0656,46562.947,2817.33014.71482.33922,55690.9
Matt RyanMatt Ryan211272.25,0337,68765.557,4357.53594.71622.14192,77694.6
Peyton ManningPeyton Manning266270.56,1259,38065.371,9407.75395.72512.73031,95396.5
Tom BradyTom Brady308264.56,98110,90164.081,4797.56025.51941.85303,33397.6
Kirk CousinsKirk Cousins115262.12,6193,90167.130,1417.72035.2862.22221,63398.4
Kurt WarnerKurt Warner124260.82,6664,07065.532,3447.92085.11283.12601,66993.7
Philip RiversPhilip Rivers244260.05,2778,13464.963,4407.84215.22092.64652,84295.2
Aaron RodgersAaron Rodgers204259.64,4366,80865.252,9557.84276.3921.44843,273104.1
Ben RoethlisbergerBen Roethlisberger239258.85,2038,07364.461,8637.74035.02052.55283,49793.8
Carson PalmerCarson Palmer182254.13,9416,30762.546,2477.32944.71873.03402,36487.9
Dan MarinoDan Marino242253.64,9678,35859.461,3617.34205.02523.02701,93086.4
Derek CarrDerek Carr117249.32,6484,09664.629,1657.11824.4761.92141,30692.7
Eli ManningEli Manning236241.64,8958,11960.357,0237.03664.52443.04112,87084.1
Brett FavreBrett Favre302237.96,30010,16962.071,8387.15085.03363.35253,48786.0
Dan FoutsDan Fouts181237.83,2975,60458.843,0407.72544.52424.33192,30480.2
Trent GreenTrent Green120237.32,2663,74060.628,4757.61624.31143.02591,62186.0
Warren MoonWarren Moon208237.13,9886,82358.449,3257.22914.32333.44583,41580.9
Russell WilsonRussell Wilson149235.92,9104,46065.235,1427.92776.2821.84072,664102.3
Ryan TannehillRyan Tannehill123233.62,4943,90763.828,7327.41854.7932.43242,42991.8
Joe FlaccoJoe Flacco176232.63,7446,06661.740,9316.72243.71442.43662,62384.1
Andy DaltonAndy Dalton147231.53,0104,83262.334,0347.02194.51272.63061,95887.5
Daunte CulpepperDaunte Culpepper105230.02,0163,19963.024,1537.61494.71063.32981,69687.8
Drew BledsoeDrew Bledsoe194230.03,8396,71757.244,6116.62513.72063.14673,13577.1
Jay CutlerJay Cutler153229.63,0484,92062.035,1337.12274.61603.33222,03585.3
StatMuse has season-level data for passing yards per game going back to the 1932 season.