Michael Strahan has the most sacks in a season, with 22.5 sacks in 2001.

who had the most sacks tfl of all-time in a season
Interpreted as:
Who had the most defensive sacks tfl of all-time in a season?
2001Strahan2014Houston2011Allen2018Donald2014Watt2012Watt2008Ware2019Barrett2013Mathis2012Smith2011Ware2019Jones2013Quinn2012Miller2003Strahan2002Taylor2011Babin2015Watt2008Porter2017Jones2014Dumervil2009Dumervil2006Merriman22.522.022.020.520.520.520.019.519.519.519.519.019.018.518.518.518.017.517.517.017.017.017.0
NAMESEASONTMGPSCKTFLTKLASTCOMBSCKYINTINT YDSINT TDFFFRFR TD
Michael StrahanMichael Strahan2001NYGNYG1622.524611273177.5000611
Justin HoustonJustin Houston2014KCKC1622.0236096999000400
Jared AllenJared Allen2011MINMIN1622.021481866150.51140440
Aaron DonaldAaron Donald2018LARLAR1620.525411859183.5000420
J.J. WattJ.J. Watt2014HOUHOU1620.5295919781401801451
J.J. WattJ.J. Watt2012HOUHOU1620.539691281138.5000420
DeMarcus WareDeMarcus Ware2008DALDAL1620.027691584113000610
Shaquil BarrettShaquil Barrett2019TBTB1619.519451358138.5140600
Robert MathisRobert Mathis2013INDIND1619.515441559120.5000800
Aldon SmithAldon Smith2012SFSF1619.518501666144.5160300
DeMarcus WareDeMarcus Ware2011DALDAL1619.526481058124.5000210
Chandler JonesChandler Jones2019ARIARI1619.011421153146000830
Robert QuinnRobert Quinn2013STLSTL1619.02350757145000721
Von MillerVon Miller2012DENDEN1618.528551368129.51261600
Michael StrahanMichael Strahan2003NYGNYG1618.523601575126.5000310
Jason TaylorJason Taylor2002MIAMIA1618.517462470162.5000720
Jason BabinJason Babin2011PHIPHI1618.01735540107000300
J.J. WattJ.J. Watt2015HOUHOU1617.529571976117.5000310
Joey PorterJoey Porter2008MIAMIA1617.51837114896000410
Chandler JonesChandler Jones2017ARIARI1617.02852759113000200
Elvis DumervilElvis Dumervil2014BALBAL1617.015281038127.5000210
Elvis DumervilElvis Dumervil2009DENDEN1617.0144274988.5000410
Shawne MerrimanShawne Merriman2006SDSD1217.015491463931100410
Jason Pierre-PaulJason Pierre-Paul2011NYGNYG1616.523662086112000200
John AbrahamJohn Abraham2008ATLATL1616.52037138109.5000400
StatMuse has season-level data for tackles for loss going back to the 2001 season.

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