Bobby Clarke has the most career games for the Flyers versus the Penguins, with 76 games.

flyers player most regular-season games played vs penguins

	NAME	GP	G	A	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Bobby Clarke B. Clarke	76	44	64	108	+69	69	9	15	6	5	6	1	202	21.8
2	Brian Propp B. Propp	64	25	41	66	+14	89	6	18	1	4	2	0	232	10.8
3	Claude Giroux C. Giroux	61	21	43	64	+5	28	6	21	2	0	7	2	159	13.2	611	1,091	56.0	54	22	29	16	20:06
4	Bill Barber B. Barber	58	37	30	67	+40	38	9	10	4	1	4	0	251	14.7
5	Joe Watson J. Watson	54	0	9	9	+18	28	0	1	0	1	0	0	54	0.0
6	Simon Gagne S. Gagne	53	19	22	41	+8	14	8	6	3	1	0	0	154	12.3	17	36	47.2	26	22	22	18	18:46
7	Rick Tocchet R. Tocchet	53	16	16	32	-5	213	5	5	0	1	2	0	131	12.2	0	0		12	0	2	0	13:47
8	Gary Dornhoefer G. Dornhoefer	53	16	29	45	+1	125	4	6	0	1	4	0	109	14.7
9	Mark Howe M. Howe	52	15	36	51	+43	28	7	10	4	5	2	0	135	11.1
10	Pelle Eklund P. Eklund	51	9	29	38	-1	9	2	13	1	1	1	0	85	10.6
11	Tim Kerr T. Kerr	51	30	29	59	+14	76	13	10	0	0	6	0	181	16.6
12	Sean Couturier S. Couturier	50	9	23	32	+4	14	1	2	0	1	3	2	110	8.2	436	778	56.0	42	22	39	19	18:47
13	Ilkka Sinisalo I. Sinisalo	49	26	24	50	+27	12	6	5	2	2	2	1	101	25.7
14	Ed Van Impe E. Van Impe	48	2	10	12	+24	120	0	1	0	2	0	0	70	2.9
15	Chris Therien C. Therien	47	5	6	11	+7	69	3	1	0	1	0	0	85	5.9	0	0		44	34	11	13	18:29
16	Jakub Voracek J. Voracek	46	23	26	49	0	49	8	13	0	0	2	0	143	16.1	4	10	40.0	28	21	12	29	17:40
17	Murray Craven M. Craven	45	17	23	40	+18	43	2	4	3	0	4	1	92	18.5
18	Ron Sutter R. Sutter	45	18	14	32	+13	68	3	1	0	0	3	0	96	18.8
19	Rick MacLeish R. MacLeish	45	15	24	39	+14	41	4	6	1	1	3	0	161	9.3
20	Brad Marsh B. Marsh	44	1	9	10	+25	89	0	0	0	0	0	0	55	1.8
21	Bob Kelly B. Kelly	44	9	14	23	+17	68	2	1	0	0	1	0	57	15.8
22	Eric Desjardins E. Desjardins	43	7	27	34	-2	36	4	12	1	2	1	0	120	5.8	0	1	0.0	3	34	8	17	24:55
23	Kjell Samuelsson K. Samuelsson	43	3	11	14	-4	77	0	2	0	0	0	0	72	4.2
24	Dave Brown D. Brown	43	4	7	11	-6	124	0	0	0	0	1	0	39	10.3
25	Derrick Smith D. Smith	42	7	8	15	+4	40	0	0	0	0	2	0	71	9.9