Chris Pronger has played the most career minutes per game by a defenseman, with 27.18 per game.

Interpreted as:

most minutes per game with a minimum of 250 games played career defenseman

	NAME	MIN/GP	GP	G	A	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Chris Pronger C. Pronger	27.18	738	107	405	512	+151	877	62	234	1	12	23	5	1,740	6.1	7	23	30.4	807	1,385	397	637	27:11
2	Nicklas Lidstrom N. Lidstrom	26.93	952	163	556	719	+273	350	84	297	6	14	23	4	2,426	6.7	0	0		477	990	462	638	26:56
3	Al MacInnis A. MacInnis	26.64	274	50	159	209	+67	205	27	88	2	4	16	2	1,002	5.0	2	2	100.0	152	266	129	247	26:38
4	Sergei Zubov S. Zubov	26.50	607	78	320	398	+59	194	49	176	2	6	12	2	1,258	6.2	1	1	100.0	298	467	344	835	26:30
5	Brian Leetch B. Leetch	26.47	398	70	203	273	-27	172	28	109	2	7	12	5	1,053	6.6	0	1	0.0	410	653	306	420	26:28
6	Drew Doughty D. Doughty	26.21	1,177	156	513	669	+60	769	80	217	2	7	33	8	2,443	6.4	1	3	33.3	1,999	1,573	289	1,105	26:13
7	Scott Niedermayer S. Niedermayer	25.41	737	109	354	463	+83	512	55	155	0	11	30	12	1,440	7.6	7	26	26.9	565	674	566	617	25:25
8	Erik Karlsson E. Karlsson	25.31	1,032	191	645	836	-111	472	43	254	2	5	37	11	2,852	6.7	0	4	0.0	760	1,372	823	1,194	25:19
9	Robert Svehla R. Svehla	24.94	328	29	122	151	+9	273	8	47	0	2	2	0	493	5.9	0	3	0.0	925	484	164	254	24:57
10	Rob Blake R. Blake	24.90	739	137	317	454	+41	809	81	143	3	8	21	1	2,330	5.9	5	14	35.7	1,229	1,382	452	653	24:54
11	Derian Hatcher D. Hatcher	24.89	517	25	114	139	+46	539	7	24	2	8	6	1	681	3.7	0	0		1,297	720	169	535	24:53
12	Roman Josi R. Josi	24.86	938	188	521	709	+64	389	64	190	1	9	35	9	2,776	6.8	0	2	0.0	669	1,771	352	627	24:52
13	Duncan Keith D. Keith	24.68	1,256	106	540	646	+159	675	30	156	5	15	19	3	2,526	4.2	0	1	0.0	684	2,010	650	1,002	24:41
14	Cale Makar C. Makar	24.61	345	95	277	372	+111	102	33	126	2	3	22	5	963	9.9	0	0		317	460	256	233	24:36
15	Alex Pietrangelo A. Pietrangelo	24.46	1,041	146	473	619	+117	343	38	152	1	16	33	6	2,513	5.8	1	3	33.3	740	1,998	671	589	24:27
16	Miro Heiskanen M. Heiskanen	24.45	452	57	215	272	+23	140	12	83	0	2	10	2	1,047	5.4	0	0		292	538	242	445	24:27
17	Bryan McCabe B. McCabe	24.40	820	119	313	432	+52	1,082	67	161	0	7	21	6	1,717	6.9	1	6	16.7	1,534	1,131	130	732	24:24
18	Eric Desjardins E. Desjardins	24.36	397	48	148	196	+60	225	20	53	2	7	11	2	888	5.4	4	8	50.0	120	512	193	345	24:22
19	Ryan Suter R. Suter	24.32	1,473	106	581	687	+116	775	36	218	4	12	20	2	2,390	4.4	2	5	40.0	1,180	1,974	538	721	24:19
20	Alexei Zhitnik A. Zhitnik	24.30	575	33	175	208	-31	675	15	88	0	6	5	2	1,020	3.2	1	3	33.3	838	639	177	448	24:18
21	Kris Letang K. Letang	24.22	1,114	171	583	754	+88	767	54	225	6	10	34	11	2,854	6.0	1	5	20.0	1,927	1,685	612	1,030	24:13
22	Quinn Hughes Q. Hughes	24.17	392	50	315	365	+37	165	11	151	0	3	6	3	821	6.1	0	0		108	297	220	288	24:10
23	Jay Bouwmeester J. Bouwmeester	24.12	1,240	88	336	424	-17	635	25	110	0	7	8	0	1,994	4.4	3	5	60.0	1,218	1,678	307	685	24:07
24	Kenny Jonsson K. Jonsson	24.12	356	32	109	141	-5	134	14	45	2	6	2	0	496	6.5	3	8	37.5	249	528	286	192	24:07
25	Mattias Ohlund M. Ohlund	24.10	758	77	201	278	+10	726	33	82	4	7	18	6	1,343	5.7	0	2	0.0	1,187	1,254	307	538	24:06