Between the 2019-20 and 2028-29 seasons, the Boston Bruins and the Colorado Avalanche were tied for the most wins, with 255 wins.

Interpreted as:

most regular-season wins in the 2020s

	TEAM	W	GP	L	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Bruins	255	402	100	47	557	.693	14	17	1,284	1,009	275	21.7	83.6	32.36	9.9	29.27	.914
2	Avalanche	255	402	114	33	543	.675	14	9	1,417	1,134	283	23.2	80.1	33.28	10.6	29.89	.906
3	Hurricanes	250	398	110	38	538	.676	16	13	1,312	1,030	282	23.6	85.6	33.52	9.8	27.19	.905
4	Panthers	242	400	123	35	519	.649	14	13	1,412	1,179	233	23.0	79.4	34.87	10.1	30.23	.902
5	Maple Leafs	238	400	116	46	522	.653	11	10	1,393	1,175	218	24.0	79.9	32.48	10.7	29.95	.902
6	Oilers	236	401	131	34	506	.631	9	8	1,392	1,192	200	28.0	79.7	32.40	10.7	30.52	.903
7	Golden Knights	236	401	127	38	510	.636	18	15	1,304	1,124	180	20.3	79.1	32.61	10.0	29.66	.905
8	Lightning	235	398	130	33	503	.632	11	12	1,375	1,163	212	24.9	81.6	30.58	11.3	29.97	.903
9	Rangers	233	400	132	35	501	.626	14	13	1,299	1,104	195	23.9	81.8	30.48	10.7	30.72	.910
10	Wild	227	399	128	44	498	.624	19	19	1,280	1,171	109	20.8	77.6	30.45	10.5	30.57	.904
11	Jets	225	403	149	29	479	.594	6	10	1,249	1,104	145	21.1	78.4	30.71	10.1	31.11	.912
12	Stars	222	398	125	51	495	.622	18	16	1,233	1,082	151	22.9	81.0	30.94	10.0	29.60	.908
13	Capitals	215	398	135	48	478	.601	18	17	1,272	1,202	70	20.7	81.6	29.98	10.7	29.83	.899
14	Penguins	213	401	141	47	473	.590	13	14	1,282	1,198	84	20.0	80.8	32.74	9.8	31.03	.904
15	Blues	212	402	145	45	469	.583	15	14	1,269	1,232	37	21.9	78.4	29.31	10.8	31.07	.901
16	Predators	207	400	157	36	450	.563	21	7	1,178	1,194	-16	19.9	79.0	30.78	9.6	31.65	.906
17	Kings	202	400	150	48	452	.565	14	17	1,168	1,145	23	20.1	79.5	32.09	9.1	28.57	.900
18	Flames	202	401	151	48	452	.564	14	14	1,236	1,180	56	20.1	81.3	32.90	9.4	29.31	.900
19	Canucks	201	398	154	43	445	.559	16	14	1,255	1,235	20	22.5	77.2	29.88	10.6	31.19	.901
20	Islanders	196	400	145	59	451	.564	13	23	1,133	1,110	23	18.5	79.2	29.61	9.6	31.18	.911
21	Devils	182	402	176	44	408	.507	9	22	1,231	1,302	-71	19.8	80.1	31.28	9.8	30.19	.893
22	Flyers	173	400	173	54	400	.500	18	19	1,133	1,315	-182	15.9	78.1	30.81	9.2	30.04	.891
23	Senators	170	401	193	38	378	.471	13	10	1,165	1,328	-163	19.3	78.0	31.21	9.3	31.66	.895
24	Sabres	169	400	188	43	381	.476	15	13	1,179	1,332	-153	19.9	76.7	30.21	9.8	31.73	.895
25	Red Wings	155	401	198	48	358	.446	15	12	1,078	1,379	-301	18.7	76.3	28.08	9.6	32.15	.893