The Vancouver Canucks had the highest goal differential by a team in 2010-11, with a differential of 78 goals.

	TEAM	DIFF	SEASON	GP	W	L	OTL	PTS	PTS%	SOW	SOL	G	GA	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Canucks	78	2010-11	82	54	19	9	117	.713	4	5	258	180	24.3	85.6	32.00	9.8	30.12	.927
2	Bruins	55	2010-11	82	46	25	11	103	.628	2	6	244	189	16.2	82.6	32.88	9.1	32.71	.930
3	Flyers	40	2010-11	82	47	23	12	106	.646	3	7	256	216	16.6	82.7	31.77	9.8	30.13	.913
4	Sharks	35	2010-11	82	48	25	9	105	.640	5	5	243	208	23.5	79.6	34.54	8.6	28.89	.912
5	Blackhawks	32	2010-11	82	44	29	9	97	.591	6	5	252	220	23.1	79.2	32.16	9.6	28.71	.907
6	Penguins	32	2010-11	82	49	25	8	106	.646	10	3	228	196	15.8	86.1	31.49	8.8	28.68	.917
7	Rangers	29	2010-11	82	44	33	5	93	.567	9	3	224	195	16.9	83.7	29.91	9.1	29.39	.919
8	Capitals	28	2010-11	82	48	23	11	107	.652	5	6	219	191	17.5	85.6	31.29	8.5	28.96	.920
9	Predators	23	2010-11	82	44	27	11	99	.604	6	4	213	190	15.2	84.9	28.80	9.0	30.61	.924
10	Red Wings	20	2010-11	82	47	25	10	104	.634	4	4	257	237	22.3	82.3	33.62	9.3	30.66	.906
11	Kings	13	2010-11	82	46	30	6	98	.598	10	2	209	196	16.1	85.5	28.82	8.8	27.90	.914
12	Sabres	12	2010-11	82	43	29	10	96	.585	5	1	240	228	19.4	83.0	32.80	8.9	30.66	.909
13	Flames	11	2010-11	82	41	29	12	94	.573	9	7	241	230	19.5	81.2	30.50	9.6	28.51	.902
14	Blues	8	2010-11	82	38	33	11	87	.530	4	6	236	228	18.6	81.7	30.18	9.5	27.73	.900
15	Canadiens	7	2010-11	82	44	30	8	96	.585	3	3	213	206	19.7	84.4	31.73	8.2	30.95	.919
16	Lightning	7	2010-11	82	46	25	11	103	.628	6	6	241	234	20.5	83.8	31.77	9.3	28.71	.901
17	Coyotes	6	2010-11	82	43	26	13	99	.604	5	6	226	220	15.9	78.4	30.32	9.1	32.60	.918
18	Ducks	2	2010-11	82	47	30	5	99	.604	4	2	235	233	23.5	81.3	28.46	10.1	32.29	.912
19	Hurricanes	-3	2010-11	82	40	31	11	91	.555	5	5	231	234	15.9	81.3	30.70	9.2	33.23	.914
20	Stars	-4	2010-11	82	42	29	11	95	.579	5	7	222	226	18.0	80.1	27.67	9.8	30.54	.910
21	Wild	-25	2010-11	82	39	35	8	86	.524	3	5	203	228	18.2	82.8	26.20	9.5	32.01	.913
22	Panthers	-31	2010-11	82	30	40	12	72	.439	4	7	191	222	13.1	84.6	30.40	7.7	31.82	.915
23	Maple Leafs	-32	2010-11	82	37	34	11	85	.518	5	6	213	245	16.0	77.5	28.78	9.0	30.98	.904
24	Islanders	-33	2010-11	82	30	39	13	73	.445	4	6	225	258	17.2	83.2	29.37	9.3	31.95	.902
25	Devils	-36	2010-11	82	38	39	5	81	.494	3	2	171	207	14.3	83.4	28.59	7.3	26.24	.904