The Ottawa Senators had the highest goal differential by a team in 2005-06, with a differential of 107 goals.

	TEAM	DIFF	SEASON	GP	W	L	OTL	PTS	PTS%	SOW	SOL	G	GA	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Senators	107	2005-06	82	52	21	9	113	.689	2	6	312	205	20.8	84.7	34.28	11.1	28.59	.913
2	Red Wings	95	2005-06	82	58	16	8	124	.756	4	3	301	206	22.1	85.5	34.10	10.8	26.59	.906
3	Sabres	42	2005-06	82	52	24	6	110	.671	5	5	276	234	21.2	86.6	30.61	11.0	30.51	.906
4	Rangers	39	2005-06	82	44	26	12	100	.610	7	4	250	211	18.9	83.7	29.85	10.2	28.76	.911
5	Stars	36	2005-06	82	53	23	6	112	.683	12	1	253	217	17.7	83.7	28.49	10.8	25.60	.897
6	Sharks	30	2005-06	82	44	27	11	99	.604	1	7	265	235	18.2	80.7	30.28	10.7	26.59	.892
7	Avalanche	29	2005-06	82	43	30	9	95	.579	3	6	280	251	18.8	84.6	30.05	11.4	29.45	.896
8	Mighty Ducks	29	2005-06	82	43	27	12	98	.598	3	7	251	222	18.1	83.5	31.52	9.7	29.65	.909
9	Predators	29	2005-06	82	49	25	8	106	.646	6	3	253	224	18.4	84.6	29.02	10.6	32.46	.916
10	Hurricanes	28	2005-06	82	52	22	8	112	.683	8	2	286	258	17.9	81.8	31.13	11.2	30.45	.897
11	Flames	23	2005-06	82	46	25	11	103	.628	2	7	216	193	18.2	84.3	28.04	9.4	27.57	.915
12	Wild	14	2005-06	82	38	36	8	84	.512	5	3	226	212	17.0	87.4	26.76	10.3	30.00	.914
13	Flyers	10	2005-06	82	45	26	11	101	.616	4	6	263	253	18.0	79.1	31.12	10.3	28.93	.893
14	Devils	8	2005-06	82	46	27	9	101	.616	9	4	233	225	17.8	81.9	29.21	9.7	29.30	.906
15	Oilers	7	2005-06	82	41	28	13	95	.579	7	9	249	242	18.1	84.1	29.78	10.2	25.55	.884
16	Thrashers	6	2005-06	82	41	33	8	90	.549	5	5	276	270	18.9	79.2	30.76	10.9	30.28	.891
17	Canucks	1	2005-06	82	42	32	8	92	.561	4	4	252	251	18.3	81.8	28.76	10.7	30.07	.898
18	Canadiens	-3	2005-06	82	42	31	9	93	.567	2	3	241	244	19.2	81.1	30.12	9.8	30.57	.903
19	Maple Leafs	-9	2005-06	82	41	33	8	90	.549	3	7	254	263	21.4	80.0	28.33	10.9	30.60	.895
20	Lightning	-10	2005-06	82	43	33	6	92	.561	6	4	246	256	16.7	81.5	31.63	9.5	27.56	.887
21	Panthers	-16	2005-06	82	37	34	11	85	.518	4	5	236	252	15.3	82.3	33.22	8.7	34.79	.912
22	Kings	-26	2005-06	82	42	35	5	89	.543	6	1	243	269	14.2	78.7	29.20	10.2	29.99	.891
23	Coyotes	-26	2005-06	82	38	39	5	81	.494	4	3	242	268	17.7	80.9	28.27	10.4	30.24	.892
24	Bruins	-30	2005-06	82	29	37	16	74	.451	2	8	228	258	14.8	83.7	30.62	9.1	32.11	.902
25	Islanders	-54	2005-06	82	36	40	6	78	.476	9	3	221	275	16.9	79.2	30.26	8.9	31.09	.892