Martin Brodeur has the most career wins by a goalie against the Penguins, with 48 wins.

goalie most regular-season wins vs penguins all-time

	NAME	W	GP	GS	L	T	OTL	SA	SV	SV%	GA	GAA	SHO	MIN
1	Martin Brodeur M. Brodeur	48	84	71	28	4	1	2,018	1,825	.904	193	2.45	9	4728
2	Rogie Vachon R. Vachon	34	64		19	8		1,821	1,647	.904	174	2.83	7	3691
3	Tony Esposito T. Esposito	30	48		11	7		1,571	1,447	.921	124	2.59	5	2876
4	Henrik Lundqvist H. Lundqvist	29	64	64	24	0	11	1,853	1,688	.911	165	2.60	4	3809
5	John Vanbiesbrouck J. Vanbiesbrouck	27	63	9	22	5	0	1,672	1,470	.879	202	3.61	1	3353
6	Patrick Roy P. Roy	25	40	9	8	6	0	1,144	1,048	.916	96	2.44	0	2356
7	Kelly Hrudey K. Hrudey	22	36	1	11	1		1,094	984	.899	110	3.17	2	2082
8	Sean Burke S. Burke	21	45	15	16	6	0	1,279	1,137	.889	142	3.32	2	2565
9	Billy Smith B. Smith	21	44		10	11		1,377	1,240	.901	137	3.24	1	2539
10	Bernie Parent B. Parent	21	36		9	6		1,089	1,018	.935	71	1.97	10	2158
11	Jose Theodore J. Theodore	20	30	29	5	1	3	858	786	.916	72	2.40	4	1803
12	Ron Hextall R. Hextall	20	41	5	15	3		1,052	934	.888	118	3.06	0	2310
13	Bob Froese B. Froese	20	30		4	3		825	744	.902	81	2.90	0	1675
14	Ed Giacomin E. Giacomin	20	32		7	4		895	821	.917	74	2.34	7	1898
15	Sergei Bobrovsky S. Bobrovsky	19	35	34	10	0	6	1,075	983	.914	92	2.68	0	2060
16	Cam Ward C. Ward	19	35	35	12	0	4	1,085	998	.920	87	2.46	1	2119
17	Cesare Maniago C. Maniago	18	39		12	6		1,292	1,187	.919	105	2.85	5	2208
18	Pete Peeters P. Peeters	17	32		7	1		785	701	.893	84	3.00	3	1678
19	Roberto Luongo R. Luongo	16	36	36	11	1	6	1,093	990	.906	103	2.98	4	2072
20	Michel Larocque M. Larocque	16	26		4	6		691	620	.897	71	2.80	1	1519
21	Ron Low R. Low	16	34		12	2		1,001	892	.891	109	3.61	0	1810
22	Ed Belfour E. Belfour	15	23	14	5	1	1	594	539	.907	55	2.50	2	1322
23	Mike Liut M. Liut	15	23		7	1		617	533	.864	84	3.94	1	1278
24	Dan Bouchard D. Bouchard	15	27		9	3		734	663	.903	71	2.79	2	1529
25	Ken Dryden K. Dryden	15	21		3	2		630	577	.916	53	2.62	1	1213