Martin Brodeur has the most career wins by a goalie against the Sabres, with 33 wins.

regular-season winningest goalie against the sabres all-time

	NAME	W	GP	GS	L	T	OTL	SA	SV	SV%	GA	GAA	SHO	MIN
1	Martin Brodeur M. Brodeur	33	62	48	16	5	4	1,485	1,359	.915	126	2.11	3	3576
2	Patrick Roy P. Roy	24	55	7	20	7	0	1,407	1,269	.902	138	2.66	5	3117
3	Marc-Andre Fleury M. Fleury	23	36	33	7	0	4	980	902	.920	78	2.21	4	2118
4	Henrik Lundqvist H. Lundqvist	22	38	37	13	0	2	1,068	984	.921	84	2.31	2	2184
5	Mike Liut M. Liut	22	46		20	2		1,257	1,120	.891	137	3.12	1	2634
6	Brian Elliott B. Elliott	20	28	25	5	0	2	776	720	.928	56	2.13	5	1576
7	Craig Anderson C. Anderson	20	34	33	10	0	2	1,013	940	.928	73	2.33	3	1877
8	Roberto Luongo R. Luongo	20	32	32	9	2	0	926	863	.932	63	2.02	5	1867
9	Tuukka Rask T. Rask	19	30	29	7	0	1	877	818	.933	59	2.10	2	1690
10	Dan Bouchard D. Bouchard	19	49		19	10		1,427	1,268	.889	159	3.29	2	2899
11	Carey Price C. Price	18	39	39	12	0	9	1,179	1,097	.930	82	2.07	2	2374
12	Bernie Parent B. Parent	18	24		2	3		622	568	.913	54	2.32	1	1399
13	Cam Ward C. Ward	17	32	32	10	0	5	915	831	.908	84	2.73	2	1845
14	Andy Moog A. Moog	17	44	2	20	5		1,276	1,139	.893	137	3.20	4	2570
15	Sergei Bobrovsky S. Bobrovsky	16	26	26	7	0	2	747	684	.916	63	2.59	1	1462
16	Olie Kolzig O. Kolzig	16	34	30	15	2	0	914	830	.908	84	2.54	1	1986
17	Curtis Joseph C. Joseph	16	28	19	8	4	0	780	711	.912	69	2.52	1	1645
18	Pete Peeters P. Peeters	16	34		14	2		905	803	.887	102	3.08	1	1989
19	Billy Smith B. Smith	16	44		22	5		1,331	1,192	.896	139	3.26	1	2559
20	Tony Esposito T. Esposito	16	40		16	8		1,226	1,115	.909	111	2.78	2	2396
21	Ron Hextall R. Hextall	15	28	2	9	2		731	651	.891	80	3.00	1	1598
22	James Reimer J. Reimer	14	21	19	4	0	2	642	583	.908	59	2.97	1	1194
23	Tim Thomas T. Thomas	14	30	25	9	0	4	837	754	.901	83	2.96	0	1682
24	Mike Richter M. Richter	14	34	17	13	7	0	984	899	.914	85	2.50	3	2036
25	Ron Tugnutt R. Tugnutt	14	32	12	12	5	0	862	789	.915	73	2.40	5	1822