Deandre Ayton has averaged 13.4 points, 10.7 rebounds and 2.0 assists in 9 games versus the Cavaliers in his career.
| NAME | DATE | TM | OPP | MIN | PTS | REB | AST | STL | BLK | TOV | FGM | FGA | FG% | 3PM | 3PA | 3P% | FTM | FTA | FT% | PF | +/- | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Deandre Ayton | 2/21/2019 |  PHX | @ |  CLE | 35 | 13 | 9 | 3 | 1 | 0 | 1 | 5 | 9 | 55.6 | 0 | 0 | 3 | 6 | 50.0 | 0 | -21 | |
| | Deandre Ayton | 2/8/2021 | PHX | vs | CLE | 37 | 15 | 16 | 2 | 0 | 3 | 1 | 7 | 11 | 63.6 | 0 | 0 | 1 | 2 | 50.0 | 2 | +4 | |
| | Deandre Ayton | 5/4/2021 | PHX | @ | CLE | 36 | 15 | 8 | 1 | 1 | 5 | 3 | 7 | 10 | 70.0 | 0 | 0 | 1 | 1 | 100.0 | 3 | +15 | |
| | Deandre Ayton | 10/30/2021 | PHX | vs | CLE | 24 | 17 | 12 | 1 | 3 | 0 | 2 | 8 | 10 | 80.0 | 0 | 1 | 0.0 | 1 | 3 | 33.3 | 1 | +30 |
| | Deandre Ayton | 11/24/2021 | PHX | @ | CLE | 27 | 16 | 10 | 1 | 1 | 0 | 3 | 8 | 12 | 66.7 | 0 | 0 | 0 | 0 | 5 | +4 | ||
| | Deandre Ayton | 1/4/2023 | PHX | @ | CLE | 37 | 15 | 18 | 1 | 1 | 0 | 3 | 7 | 12 | 58.3 | 0 | 1 | 0.0 | 1 | 2 | 50.0 | 2 | -5 |
| | Deandre Ayton | 1/8/2023 | PHX | vs | CLE | 30 | 14 | 11 | 6 | 0 | 1 | 0 | 6 | 16 | 37.5 | 0 | 0 | 2 | 2 | 100.0 | 2 | -5 | |
 | Deandre Ayton | 11/15/2023 |  POR | vs | CLE | 26 | 6 | 6 | 0 | 0 | 0 | 2 | 3 | 10 | 30.0 | 0 | 0 | 0 | 0 | 3 | -14 | ||
| | Deandre Ayton | 11/30/2023 | POR | @ | CLE | 30 | 10 | 6 | 3 | 0 | 0 | 3 | 5 | 9 | 55.6 | 0 | 0 | 0 | 0 | 2 | -6 |
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