The San Antonio Spurs had their highest point differential in a game versus the 76ers on December 7, 2015, with a 51 point differential.

san antonio spurs largest point differential in a game

Interpreted as:

san antonio spurs largest point differential in a regular-season game

TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	TOV	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	PF
San Antonio Spurs	51	12/7/2015	SAS	@	PHI	W 119-68	240	119	47	32	4	1	7	47	76	61.8	4	11	36.4	21	25	84.0	17
San Antonio Spurs	49	11/8/1995	SAS	vs	VAN	W 111-62	240	111	44	30	10	11	14	39	79	49.4	7	17	41.2	26	33	78.8	18
San Antonio Spurs	48	2/7/2018	SAS	@	PHX	W 129-81	240	129	62	26	6	6	12	46	93	49.5	16	32	50.0	21	27	77.8	17
San Antonio Spurs	45	1/8/1985	SAS	vs	GSW	W 139-94	240	139	58	41	17	7	27	56	90	62.2	0	2	0.0	27	35	77.1	31
San Antonio Spurs	42	1/10/1998	SAS	vs	SAC	W 109-67	240	109	52	30	10	3	11	44	79	55.7	4	9	44.4	17	30	56.7	15
San Antonio Spurs	42	10/14/1978	SAS	vs	MIL	W 153-111	240	153	57	39	13	4	14	60	107	56.1				33	41	80.5	28
San Antonio Spurs	41	3/25/2007	SAS	@	SEA	W 120-79	240	120	38	26	10	6	11	41	77	53.2	16	31	51.6	22	26	84.6	20
San Antonio Spurs	41	11/1/1991	SAS	vs	DAL	W 140-99	240	140	47	38	8	9	10	53	93	57.0	2	7	28.6	32	34	94.1	24
San Antonio Spurs	41	11/25/1978	SAS	vs	NJN	W 151-110	240	151	48	39	21	3	17	58	101	57.4				35	43	81.4	25
San Antonio Spurs	40	1/12/2017	SAS	vs	LAL	W 134-94	240	134	46	32	5	5	12	49	81	60.5	10	21	47.6	26	29	89.7	20
San Antonio Spurs	40	12/4/2006	SAS	vs	GSW	W 129-89	240	129	51	37	5	5	12	49	94	52.1	13	23	56.5	18	19	94.7	18
San Antonio Spurs	39	12/19/2018	SAS	@	ORL	W 129-90	240	129	45	29	5	4	11	50	77	64.9	12	19	63.2	17	21	81.0	15
San Antonio Spurs	39	11/11/2017	SAS	vs	CHI	W 133-94	240	133	44	33	5	6	13	51	85	60.0	18	27	66.7	13	16	81.3	16
San Antonio Spurs	39	3/25/2015	SAS	vs	OKC	W 130-91	240	130	49	28	7	4	10	51	88	58.0	13	21	61.9	15	19	78.9	12
San Antonio Spurs	39	3/3/2013	SAS	vs	DET	W 114-75	240	114	49	35	12	9	11	45	89	50.6	9	20	45.0	15	20	75.0	18
San Antonio Spurs	39	11/21/2003	SAS	vs	ATL	W 114-75	240	114	50	28	16	9	13	44	85	51.8	8	15	53.3	18	24	75.0	23
San Antonio Spurs	38	12/13/2018	SAS	vs	LAC	W 125-87	240	125	47	25	10	7	11	48	83	57.8	10	22	45.5	19	24	79.2	20
San Antonio Spurs	38	12/23/2012	SAS	vs	DAL	W 129-91	240	129	41	33	17	5	16	47	84	56.0	20	30	66.7	15	19	78.9	22
San Antonio Spurs	38	12/30/1995	SAS	vs	MIN	W 122-84	240	122	57	33	10	13	19	43	88	48.9	13	24	54.2	23	31	74.2	20
San Antonio Spurs	38	1/15/1982	SAS	vs	HOU	W 128-90	240	128	62	41	7	10	20	53	94	56.4	1	6	16.7	21	25	84.0	21
San Antonio Spurs	38	11/8/1978	SAS	vs	SDC	W 163-125	240	163	61	46	11	8	18	68	116	58.6				27	36	75.0	23
San Antonio Spurs	37	3/23/2022	SAS	@	POR	W 133-96	240	133	53	34	8	11	13	46	94	48.9	19	44	43.2	22	24	91.7	13
San Antonio Spurs	37	12/14/2015	SAS	vs	UTA	W 118-81	240	118	48	24	6	2	11	42	75	56.0	9	21	42.9	25	27	92.6	17
San Antonio Spurs	37	3/26/2007	SAS	@	GSW	W 126-89	240	126	46	33	9	3	18	43	72	59.7	10	17	58.8	30	35	85.7	22
San Antonio Spurs	36	1/12/2024	SAS	vs	CHA	W 135-99	240	135	45	31	9	7	14	45	87	51.7	18	38	47.4	27	34	79.4	20