Jerry Hughes had 235 solo tackles, 115 assists, 53.0 sacks, 5 fumble recoveries and 1 interception in 144 games for the Bills in his career.
| NAME | SEASON | TM | GP | TKL | AST | COMB | SCK | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Jerry Hughes | 2013 |  BUF | 16 | 32 | 14 | 46 | 10.0 | 65.5 | 0 | 0 | 0 | 2 | 0 | 0 |
| | Jerry Hughes | 2014 | BUF | 16 | 36 | 17 | 53 | 10.0 | 64 | 0 | 0 | 0 | 3 | 1 | 1 |
| | Jerry Hughes | 2015 | BUF | 16 | 37 | 15 | 52 | 5.0 | 63 | 0 | 0 | 0 | 2 | 1 | 0 |
| | Jerry Hughes | 2016 | BUF | 16 | 31 | 17 | 48 | 6.0 | 56 | 0 | 0 | 0 | 1 | 0 | 0 |
| | Jerry Hughes | 2017 | BUF | 16 | 28 | 16 | 44 | 4.0 | 24 | 0 | 0 | 0 | 1 | 0 | 0 |
| | Jerry Hughes | 2018 | BUF | 16 | 30 | 7 | 37 | 7.0 | 42.5 | 0 | 0 | 0 | 3 | 0 | 0 |
| | Jerry Hughes | 2019 | BUF | 16 | 14 | 9 | 23 | 4.5 | 27.5 | 0 | 0 | 0 | 0 | 1 | 0 |
| | Jerry Hughes | 2020 | BUF | 15 | 19 | 10 | 29 | 4.5 | 20 | 1 | -3 | 0 | 2 | 2 | 1 |
| | Jerry Hughes | 2021 | BUF | 17 | 8 | 10 | 18 | 2.0 | 8.5 | 0 | 0 | 0 | 2 | 0 | 0 |
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