Kyle Orton has the most passing yards in a game against Indiana, with 522 yards on November 20, 2004.

Interpreted as:

most passing yards by a player in a game against indiana

	NAME	YDS	DATE	TM		OPP	CMP	ATT	PCT	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Kyle Orton K. Orton	522	11/20/2004	PUR	vs	IND	33	54	61.1	9.7	6	0	179.0	11.1	0.0
2	John Paddock J. Paddock	507	11/11/2023	ILL	vs	IND	24	36	66.7	14.1	4	1	216.1	11.1	2.8	1	8
3	Devin Gardner D. Gardner	503	10/19/2013	MICH	vs	IND	21	29	72.4	17.3	2	0	240.9	6.9	0.0	2	22
4	Danny Etling D. Etling	485	11/30/2013	PUR	@	IND	33	49	67.3	9.9	4	0	177.4	8.2	0.0	2	13
5	Brian Brunner B. Brunner	485	11/1/2008	CMU	@	IND	35	53	66.0	9.2	4	1	164.0	7.5	1.9
6	Brandon Doughty B. Doughty	484	9/19/2015	WKU	@	IND	35	46	76.1	10.5	3	2	177.3	6.5	4.3	0	0
7	Dwayne Haskins D. Haskins	455	10/6/2018	OSU	vs	IND	33	44	75.0	10.3	6	2	197.8	13.6	4.5	1	8
8	Nathan Scheelhaase N. Scheelhaase	450	11/9/2013	ILL	@	IND	38	57	66.7	7.9	2	1	141.1	3.5	1.8	1	8
9	Curtis Painter C. Painter	448	11/22/2008	PUR	vs	IND	38	54	70.4	8.3	5	0	170.6	9.3	0.0
10	Jake Rudock J. Rudock	440	11/14/2015	MICH	@	IND	33	46	71.7	9.6	6	1	190.8	13.0	2.2	1	7
11	Scott Mullen S. Mullen	426	10/23/1999	IOWA	vs	IND	36	60	60.0	7.1	0	2	113.0	0.0	3.3
12	Taulia Tagovailoa T. Tagovailoa	419	10/30/2021	MD	vs	IND	26	40	65.0	10.5	2	0	169.5	5.0	0.0	2	18
13	Aidan O'Connell A. O'Connell	408	11/30/2019	PUR	vs	IND	28	49	57.1	8.3	3	1	143.2	6.1	2.0	1	13
14	Philip Rivers P. Rivers	401	9/9/2000	NCST	@	IND	31	52	59.6	7.7	5	1	152.3	9.6	1.9
15	Connor Cook C. Cook	398	10/24/2015	MSU	vs	IND	30	52	57.7	7.7	4	0	147.4	7.7	0.0	4	22
16	James Knapke J. Knapke	395	9/13/2014	BGSU	vs	IND	46	73	63.0	5.4	3	1	119.3	4.1	1.4	1	3
17	Matt McGloin M. McGloin	395	11/17/2012	PSU	vs	IND	22	32	68.8	12.3	4	1	207.4	12.5	3.1
18	Chris Laviano C. Laviano	386	10/17/2015	RUTG	@	IND	28	42	66.7	9.2	3	1	162.7	7.1	2.4	1	9
19	Jon Beutjer J. Beutjer	380	9/30/2000	IOWA	@	IND	30	47	63.8	8.1	4	0	159.8	8.5	0.0
20	Bryan Cupito B. Cupito	378	11/4/2006	MINN	vs	IND	22	33	66.7	11.5	4	0	202.9	12.1	0.0
21	Tim Lester T. Lester	371	9/12/1998	WMU	@	IND	28	51	54.9	7.3	2	2	121.1	3.9	3.9
22	Shea Patterson S. Patterson	366	11/23/2019	MICH	@	IND	20	32	62.5	11.4	5	1	203.9	15.6	3.1	2	17
23	Bailey Zappe B. Zappe	365	9/25/2021	WKU	vs	IND	31	44	70.5	8.3	3	0	162.6	6.8	0.0	0	0
24	Ben Bryant B. Bryant	354	9/24/2022	CIN	vs	IND	24	40	60.0	8.9	4	1	162.3	10.0	2.5	2	15
25	Taulia Tagovailoa T. Tagovailoa	352	9/30/2023	MD	vs	IND	24	34	70.6	10.4	5	0	206.1	14.7	0.0	1	7