Tim Couch has the most passing yards in a game against Louisville, with 498 yards on September 5, 1998.

Interpreted as:

most passing yards by a player in a game against louisville

	NAME	YDS	DATE	TM		OPP	CMP	ATT	PCT	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Tim Couch T. Couch	498	9/5/1998	UK	@	LOU	29	39	74.4	12.8	0	0	181.6	0.0	0.0
2	Brennan Armstrong B. Armstrong	487	10/9/2021	UVA	@	LOU	40	60	66.7	8.1	3	2	144.7	5.0	3.3	5	31
3	John Wolford J. Wolford	461	10/28/2017	WAKE	vs	LOU	28	34	82.4	13.6	5	0	244.8	14.7	0.0	1	5
4	Mike Teel M. Teel	447	12/4/2008	RUTG	vs	LOU	21	26	80.8	17.2	7	0	314.0	26.9	0.0
5	Dusty Bonner D. Bonner	446	9/4/1999	UK	vs	LOU	34	62	54.8	7.2	3	2	124.8	4.8	3.2
6	Josh Heupel J. Heupel	429	9/25/1999	OKLA	@	LOU	29	42	69.0	10.2	0	1	150.1	0.0	2.4
7	Andrew Robinson A. Robinson	423	9/22/2007	SYR	@	LOU	17	26	65.4	16.3	4	0	252.8	15.4	0.0
8	Geno Smith G. Smith	410	11/5/2011	WVU	vs	LOU	31	44	70.5	9.3	3	0	171.2	6.8	0.0
9	Jameis Winston J. Winston	401	10/30/2014	FSU	@	LOU	25	48	52.1	8.4	3	3	130.4	6.3	6.3	2	23
10	Tim Couch T. Couch	398	8/30/1997	UK	vs	LOU	36	50	72.0	8.0	4	1	161.3	8.0	2.0
11	Matt Corral M. Corral	381	9/6/2021	MISS	vs	LOU	22	32	68.8	11.9	1	0	179.1	3.1	0.0	2	13
12	Ben Roethlisberger B. Roethlisberger	376	12/18/2003	M-OH	vs	LOU	21	33	63.6	11.4	4	0	199.3	12.1	0.0
13	Kevin Kolb K. Kolb	375	11/20/2004	HOU	vs	LOU	29	44	65.9	8.5	2	1	148.0	4.5	2.3
14	Demond Williams Jr. D. Williams Jr.	374	12/31/2024	WASH	vs	LOU	26	32	81.3	11.7	4	1	214.4	12.5	3.1	5	23
15	Miller Moss M. Moss	372	12/27/2023	USC	vs	LOU	23	33	69.7	11.3	6	1	218.3	18.2	3.0	0	0
16	Everett Golson E. Golson	372	10/17/2015	FSU	vs	LOU	26	38	68.4	9.8	3	0	176.7	7.9	0.0	2	22
17	Ryan Finley R. Finley	367	10/5/2017	NCST	vs	LOU	20	31	64.5	11.8	1	0	174.6	3.2	0.0	0	0
18	Bryn Renner B. Renner	363	9/15/2012	UNC	@	LOU	26	41	63.4	8.9	5	1	173.2	12.2	2.4
19	Danny Wimprine D. Wimprine	361	11/4/2004	MEM	vs	LOU	24	46	52.2	7.8	4	1	142.4	8.7	2.2
20	Arkelon Hall A. Hall	350	10/10/2008	MEM	vs	LOU	33	55	60.0	6.4	2	1	121.8	3.6	1.8
21	Matt Grothe M. Grothe	344	10/25/2008	USF	@	LOU	30	40	75.0	8.6	2	2	153.7	5.0	5.0
22	Jason McKinley J. McKinley	342	10/25/1997	HOU	@	LOU	26	42	61.9	8.1	2	0	146.0	4.8	0.0
23	Stephen Johnson S. Johnson	338	11/26/2016	UK	@	LOU	16	27	59.3	12.5	3	1	193.7	11.1	3.7	0	0
24	Gino Guidugli G. Guidugli	336	11/28/2003	CIN	vs	LOU	20	40	50.0	8.4	1	0	128.8	2.5	0.0
25	Tyler Van Dyke T. Van Dyke	327	11/18/2023	MIA	vs	LOU	24	39	61.5	8.4	1	0	140.4	2.6	0.0	1	10