Michael Penix Jr. has the most passing yards in a game against Ohio State, with 491 yards on November 21, 2020.

Interpreted as:

most passing yards by a player in a game against ohio state

	NAME	YDS	DATE	TM		OPP	CMP	ATT	PCT	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Michael Penix Jr. M. Penix Jr.	491	11/21/2020	IND	@	OSU	27	51	52.9	9.6	5	1	162.2	9.8	2.0	2	11
2	Mac Jones M. Jones	464	1/11/2021	ALA	vs	OSU	36	45	80.0	10.3	5	0	203.3	11.1	0.0	2	7
3	Drew Brees D. Brees	455	10/28/2000	PUR	vs	OSU	39	65	60.0	7.0	3	4	121.7	4.6	6.2
4	Devin Gardner D. Gardner	451	11/30/2013	MICH	vs	OSU	32	45	71.1	10.0	4	0	184.6	8.9	0.0	3	24
5	Davis Brin D. Brin	428	9/18/2021	TLSA	@	OSU	31	54	57.4	7.9	2	2	128.8	3.7	3.7	2	27
6	Colt McCoy C. McCoy	414	1/5/2009	TEX	vs	OSU	41	58	70.7	7.1	2	1	138.6	3.4	1.7
7	Richard Lagow R. Lagow	411	8/31/2017	IND	vs	OSU	40	65	61.5	6.3	3	2	123.7	4.6	3.1	5	29
8	Trevor Lawrence T. Lawrence	400	1/1/2021	CLEM	vs	OSU	33	48	68.8	8.3	2	1	148.3	4.2	2.1	2	19
9	Stetson Bennett S. Bennett	398	12/31/2022	UGA	vs	OSU	23	34	67.6	11.7	3	1	189.2	8.8	2.9	2	12
10	Bryan Cupito B. Cupito	396	10/29/2005	MINN	vs	OSU	26	35	74.3	11.3	1	0	178.8	2.9	0.0
11	Aidan O'Connell A. O'Connell	390	11/13/2021	PUR	@	OSU	40	52	76.9	7.5	4	0	165.3	7.7	0.0	0	0
12	Baker Mayfield B. Mayfield	386	9/9/2017	OKLA	@	OSU	27	35	77.1	11.0	3	0	198.1	8.6	0.0	2	13
13	David Blough D. Blough	378	10/20/2018	PUR	vs	OSU	25	43	58.1	8.8	3	0	155.0	7.0	0.0	2	14
14	Tajh Boyd T. Boyd	378	1/3/2014	CLEM	@	OSU	31	40	77.5	9.5	5	2	188.1	12.5	5.0	2	10
15	Tom Brady T. Brady	375	11/21/1998	MICH	@	OSU	31	56	55.4	6.7	1	2	110.4	1.8	3.6
16	Sean Clifford S. Clifford	371	10/29/2022	PSU	vs	OSU	32	47	68.1	7.9	3	3	142.7	6.4	6.4	3	18
17	Jared Goff J. Goff	371	9/14/2013	CAL	vs	OSU	31	53	58.5	7.0	3	1	132.2	5.7	1.9	3	17
18	Sean Clifford S. Clifford	361	10/30/2021	PSU	@	OSU	35	52	67.3	6.9	1	1	128.1	1.9	1.9	4	22
19	Connor Cook C. Cook	358	11/8/2014	MSU	vs	OSU	25	45	55.6	8.0	2	0	137.0	4.4	0.0	2	3
20	Sam Darnold S. Darnold	356	12/29/2017	USC	@	OSU	26	45	57.8	7.9	0	1	119.8	0.0	2.2	8	47
21	Gunner Kiel G. Kiel	352	9/27/2014	CIN	@	OSU	21	32	65.6	11.0	4	0	199.3	12.5	0.0	1	25
22	Jeff Smoker J. Smoker	351	11/8/2003	MSU	@	OSU	35	55	63.6	6.4	2	2	122.0	3.6	3.6
23	Deontey Kenner D. Kenner	343	9/25/1999	CIN	@	OSU	29	52	55.8	6.6	0	2	103.5	0.0	3.8
24	John Reeves J. Reeves	342	10/19/1996	PUR	vs	OSU	20	40	50.0	8.6	2	3	123.3	5.0	7.5
25	Dillon Gabriel D. Gabriel	341	10/12/2024	ORE	vs	OSU	23	34	67.6	10.0	2	0	171.3	5.9	0.0	0	0