Donnel Pumphrey has the most career yards from scrimmage, with 7,446 yards.

Interpreted as:

most yards from scrimmage by a player in a career

	NAME	YDS	GP	RUSH YDS	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Donnel Pumphrey D. Pumphrey	7,446	54	6,405	1,059	6.0	118.6	62	1,041	100	124	10.4	19.3	5
2	Ricky Williams R. Williams	7,206	46	6,279	1,011	6.2	136.5	72	927	85		10.9	20.2	3
3	DeAngelo Williams D. Williams	6,749	44	6,026	969	6.2	137.0	55	723	70		10.3	16.4	5
4	Ron Dayne R. Dayne	6,701	43	6,397	1,115	5.7	148.8	63	304	31		9.8	7.1	0
5	Jonathan Taylor J. Taylor	6,581	41	6,174	926	6.7	150.6	50	407	42	67	9.7	9.9	5
6	Tony Dorsett T. Dorsett	6,486	44	6,082	1,074	5.7	138.2	55	404	38		10.6	9.2	4
7	Royce Freeman R. Freeman	6,435	51	5,621	947	5.9	110.2	60	814	79	91	10.3	16.0	4
8	Mewelde Moore M. Moore	6,423	44	4,364	910	4.8	99.2	21	2,059	189		10.9	46.8	15
9	Darrin Nelson D. Nelson	6,401	44	4,033	703	5.7	91.7	24	2,368	214		11.1	53.8	16
10	Justin Jackson J. Jackson	6,298	51	5,440	1,142	4.8	106.7	41	858	122	165	7.0	16.8	1
11	Damion Fletcher D. Fletcher	6,206	50	5,302	1,009	5.3	106.0	44	904	109		8.3	18.1	2
12	Cedric Benson C. Benson	6,161	48	5,540	1,112	5.0	115.4	64	621	69		9.0	12.9	3
13	Travis Prentice T. Prentice	6,118	44	5,596	1,138	4.9	127.2	73	522	54		9.7	11.9	5
14	Travis Etienne T. Etienne	6,107	55	4,952	686	7.2	90.0	70	1,155	102	128	11.3	21.0	8
15	Charles White C. White	6,105	45	5,598	1,023	5.5	124.4	46	507	54		9.4	11.3	3
16	Garrett Wolfe G. Wolfe	6,022	34	5,434	849	6.4	159.8	54	588	58		10.1	17.3	5
17	Ito Smith I. Smith	5,982	51	4,536	820	5.5	88.9	42	1,446	140	208	10.3	28.4	7
18	Steve Bartalo S. Bartalo	5,892	43	4,813	1,211	4.0	111.9	46	1,079	132		8.2	25.1	3
19	Trevor Cobb T. Cobb	5,840	44	4,948	1,091	4.5	112.5	38	892	94		9.5	20.3	5
20	Dontrell Moore D. Moore	5,830	48	4,973	1,028	4.8	103.6	51	857	92		9.3	17.9	8
21	Myles Gaskin M. Gaskin	5,788	52	5,323	945	5.6	102.4	57	465	65	91	7.2	8.9	5
22	Montee Ball M. Ball	5,738	49	5,140	924	5.6	104.9	77	598	59		10.1	12.2	6
23	Larry Rose III L. Rose III	5,729	43	4,572	771	5.9	106.3	37	1,157	133	180	8.7	26.9	5
24	Elijah McGuire E. McGuire	5,695	51	4,312	711	6.1	84.5	42	1,383	129	146	10.7	27.1	10
25	Anthony Thompson A. Thompson	5,678	44	4,965	1,089	4.6	112.8	64	713	94		7.6	16.2	1