The Notre Dame Fighting Irish are 2-2 against the Big 12 between August 31, 2014 and August 31, 2026.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Notre Dame | 9/5/2015 | 1-0 | vs | W 38-3 | 1.000 | 5 | 30 | 527 | 163 | 57.1 | |||
| 2 | | Notre Dame | 9/4/2016 | 0-1 | @ | L 47-50 | .000 | 6 | 26 | 444 | 517 | 43.8 | |||
| 3 | | Notre Dame | 12/28/2019 | 1-0 | @ | W 33-9 | 1.000 | 3 | 17 | 455 | 272 | 23.1 | 100.0 | ||
| 4 | | Notre Dame | 1/1/2022 | 0-1 | vs | L 35-37 | .000 | 5 | 27 | 551 | 605 | 55.0 | 0.0 | ||
| Average | .500 | 4.8 | 25.0 | 494.3 | 389.3 | 46.0 | 0.3 | ||||||||
| Total | 2-2 | .500 | 19 | 100 | 1,977 | 1,557 | 46.0 | 66.7 |
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