Between the 2004 and 2016 seasons, Case Keenum had the most passing touchdowns, with 155 touchdowns.

	NAME	TD	GP	CMP	ATT	PCT	YDS	AVG	YDS/G	INT	RTG	TD%	INT%	SCK	SCKY
1	Case Keenum C. Keenum	155	57	1,546	2,229	69.4	19,217	8.6	337.1	46	160.6	7.0	2.1
2	Kellen Moore K. Moore	142	53	1,157	1,658	69.8	14,667	8.8	276.7	28	169.0	8.6	1.7
3	Graham Harrell G. Harrell	134	45	1,403	2,010	69.8	15,793	7.9	351.0	34	154.4	6.7	1.7
4	Rakeem Cato R. Cato	131	53	1,153	1,838	62.7	14,079	7.7	265.6	44	145.8	7.1	2.4
5	Colt Brennan C. Brennan	131	38	1,115	1,584	70.4	14,193	9.0	373.5	42	167.6	8.3	2.7
6	Landry Jones L. Jones	123	52	1,388	2,183	63.6	16,646	7.6	320.1	52	141.5	5.6	2.4
7	Aaron Murray A. Murray	121	52	921	1,478	62.3	13,166	8.9	253.2	41	158.6	8.2	2.8
8	Matt Barkley M. Barkley	116	47	1,001	1,562	64.1	12,327	7.9	262.3	48	148.7	7.4	3.1
9	Derek Carr D. Carr	113	45	1,087	1,630	66.7	12,848	7.9	285.5	24	152.8	6.9	1.5
10	Colt McCoy C. McCoy	112	53	1,157	1,645	70.3	13,253	8.1	250.1	45	155.0	6.8	2.7
11	Brandon Doughty B. Doughty	111	43	1,023	1,491	68.6	12,856	8.6	299.0	34	161.0	7.4	2.3
12	Russell Wilson R. Wilson	109	50	907	1,489	60.9	11,720	7.9	234.4	30	147.2	7.3	2.0
13	Tajh Boyd T. Boyd	107	47	901	1,402	64.3	11,904	8.5	253.3	39	155.2	7.6	2.8
14	Marcus Mariota M. Mariota	105	41	779	1,167	66.8	10,796	9.3	263.3	14	171.8	9.0	1.2
15	Dan Lefevour D. Lefevour	102	53	1,171	1,763	66.4	12,905	7.3	243.5	36	142.9	5.8	2.0
16	Chase Daniel C. Daniel	101	51	1,094	1,609	68.0	12,515	7.8	245.4	41	148.9	6.3	2.5
17	Chase Clement C. Clement	99	45	832	1,387	60.0	9,785	7.1	217.4	34	137.9	7.1	2.5
18	Tim Hiller T. Hiller	99	44	1,013	1,607	63.0	11,329	7.0	257.5	41	137.5	6.2	2.6
19	Geno Smith G. Smith	98	44	988	1,465	67.4	11,662	8.0	265.0	21	153.5	6.7	1.4
20	Trevor Vittatoe T. Vittatoe	97	49	914	1,641	55.7	12,439	7.6	253.9	42	133.8	5.9	2.6
21	Jared Goff J. Goff	96	37	977	1,569	62.3	12,200	7.8	329.7	30	144.0	6.1	1.9	82	592
22	Zach Terrell Z. Terrell	96	49	908	1,387	65.5	12,104	8.7	247.0	31	157.1	6.9	2.2	74	417
23	Max Hall M. Hall	94	39	903	1,382	65.3	11,365	8.2	291.4	40	151.1	6.8	2.9
24	Patrick Mahomes P. Mahomes	93	32	858	1,350	63.6	11,257	8.3	351.8	29	152.0	6.9	2.1	63	456
25	Keith Wenning K. Wenning	92	48	1,035	1,642	63.0	11,402	6.9	237.5	42	134.7	5.6	2.6