Brandon West has the most career all-purpose yards by a running back, with 7,764 yards.

	NAME	YDS	GP	RUSH YDS	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Brandon West B. West	7,764	49	3,671	732	5.0	74.9	25	958	126		7.6	19.6	6
2	C.J. Spiller	7,588	52	3,547	606	5.9	68.2	32	1,420	123		11.5	27.3	11
3	DeAngelo Williams D. Williams	7,573	44	6,026	969	6.2	137.0	55	723	70		10.3	16.4	5
4	Donnel Pumphrey D. Pumphrey	7,515	54	6,405	1,059	6.0	118.6	62	1,041	100	124	10.4	19.3	5
5	Ricky Williams R. Williams	7,206	46	6,279	1,011	6.2	136.5	72	927	85		10.9	20.2	3
6	Ameer Abdullah A. Abdullah	7,186	53	4,588	813	5.6	86.6	39	690	73		9.5	13.0	7
7	Napoleon McCallum N. McCallum	7,172	55	4,179	908	4.6	76.0	31	796	96		8.3	14.5	2
8	Chris Johnson C. Johnson	6,993	47	2,982	624	4.8	63.4	32	1,296	125		10.4	27.6	10
9	Christian McCaffrey C. McCaffrey	6,987	37	3,922	632	6.2	106.0	21	1,206	99	120	12.2	32.6	10
10	Kerwynn Williams K. Williams	6,928	49	2,515	382	6.6	51.3	22	870	64		13.6	17.8	5
11	Bobby Rainey B. Rainey	6,906	43	4,542	895	5.1	105.6	35	682	80		8.5	15.9	5
12	Darrin Nelson D. Nelson	6,885	44	4,033	703	5.7	91.7	24	2,368	214		11.1	53.8	16
13	Travis Etienne T. Etienne	6,857	55	4,952	686	7.2	90.0	70	1,155	102	128	11.3	21.0	8
14	Kevin Faulk K. Faulk	6,833	41	4,557	856	5.3	111.1	46	600	53		11.3	14.6	4
15	Darren Sproles D. Sproles	6,812	45	4,979	815	6.1	110.6	45	609	66		9.2	13.5	2
16	Antonio Andrews A. Andrews	6,811	41	3,674	618	5.9	89.6	29	964	85		11.3	23.5	3
17	Demarco Murray D. Murray	6,718	50	3,685	759	4.9	73.7	50	1,571	157		10.0	31.4	13
18	Ron Dayne R. Dayne	6,701	43	6,397	1,115	5.7	148.8	63	304	31		9.8	7.1	0
19	Brock Forsey B. Forsey	6,670	47	4,045	813	5.0	86.1	50	1,175	101		11.6	25.0	18
20	Rashaad Penny R. Penny	6,654	51	3,656	488	7.5	71.7	38	479	42	56	11.4	9.4	6
21	Paul Palmer P. Palmer	6,613	44	4,895	944	5.2	111.3	39	709	87		8.1	16.1	4
22	Jonathan Taylor J. Taylor	6,581	41	6,174	926	6.7	150.6	50	407	42	67	9.7	9.9	5
23	Reggie Bush R. Bush	6,551	39	3,169	433	7.3	81.3	25	1,301	95		13.7	33.4	13
24	Ito Smith I. Smith	6,518	51	4,536	820	5.5	88.9	42	1,446	140	208	10.3	28.4	7
25	Trevor Cobb T. Cobb	6,512	44	4,948	1,091	4.5	112.5	38	892	94		9.5	20.3	5