LaDainian Tomlinson rushed for the most yards in 2000, with 2,158 yards.

	NAME	RUSH YDS	SEASON	TM	GP	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	AVG	REC YDS/G	REC TD
1	LaDainian Tomlinson L. Tomlinson	2,158	2000	TCU	11	369	5.8	196.2	22	40	10	4.0	3.6	0
2	Damien Anderson D. Anderson	1,914	2000	NW	11	293	6.5	174.0	22	120	15	8.0	10.9	0
3	Michael Bennett M. Bennett	1,598	2000	WIS	10	294	5.4	159.8	10	23	4	5.8	2.3	0
4	Deonce Whitaker D. Whitaker	1,577	2000	SJSU	10	224	7.0	157.7	15	37	3	12.3	3.7	1
5	Robert Sanford R. Sanford	1,571	2000	WMU	12	293	5.4	130.9	18	52	6	8.7	4.3	0
6	Rudi Johnson R. Johnson	1,567	2000	AUB	12	324	4.8	130.6	13	70	9	7.8	5.8	0
7	Anthony Thomas A. Thomas	1,551	2000	MICH	11	287	5.4	141.0	16	239	13	18.4	21.7	1
8	Ken Simonton K. Simonton	1,474	2000	ORST	11	266	5.5	134.0	18	14	4	3.5	1.3	0
9	Chester Taylor C. Taylor	1,470	2000	TOL	11	250	5.9	133.6	18	129	17	7.6	11.7	1
10	T.J. Duckett	1,353	2000	MSU	11	240	5.6	123.0	7	31	7	4.4	2.8	0
11	Emmett White E. White	1,322	2000	USU	11	242	5.5	120.2	13	592	47	12.6	53.8	2
12	Travis Henry T. Henry	1,314	2000	TENN	11	253	5.2	119.5	11	65	13	5.0	5.9	0
13	Dwone Hicks D. Hicks	1,277	2000	MTSU	11	186	6.9	116.1	19	181	19	9.5	16.5	2
14	Antwaan Randle El A. Randle El	1,270	2000	IND	11	218	5.8	115.5	13
15	Ennis Haywood E. Haywood	1,237	2000	ISU	10	230	5.4	123.7	8	211	25	8.4	21.1	0
16	Lee Suggs L. Suggs	1,207	2000	VT	11	222	5.4	109.7	27	44	3	14.7	4.0	1
17	Willie Alderson W. Alderson	1,195	2000	IDHO	11	238	5.0	108.6	12	420	45	9.3	38.2	3
18	William Green W. Green	1,164	2000	BC	11	187	6.2	105.8	14	78	6	13.0	7.1	1
19	Sultan McCullough S. McCullough	1,163	2000	USC	12	227	5.1	96.9	6	25	9	2.8	2.1	0
20	Michael Wallace M. Wallace	1,157	2000	ARMY	10	192	6.0	115.7	11	187	24	7.8	18.7	1
21	Dan Alexander D. Alexander	1,154	2000	NEB	11	182	6.3	104.9	8	17	2	8.5	1.5	0
22	Chris Barnes C. Barnes	1,131	2000	NMSU	11	171	6.6	102.8	5	72	8	9.0	6.5	0
23	Tellis Redmon T. Redmon	1,122	2000	MINN	11	251	4.5	102.0	6	318	29	11.0	28.9	2
24	Hodges Mitchell H. Mitchell	1,118	2000	TEX	11	224	5.0	101.6	8	386	37	10.4	35.1	3
25	Maurice Morris M. Morris	1,106	2000	ORE	11	260	4.3	100.5	8	104	18	5.8	9.5	1