Lew Nichols rushed for the most yards in 2021, with 1,848 yards.

	NAME	RUSH YDS	SEASON	TM	GP	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Lew Nichols L. Nichols	1,848	2021	CMU	13	341	5.4	142.2	16	338	40	52	8.5	26.0	2
2	Kenneth Walker III K. Walker III	1,646	2021	MSU	12	264	6.2	137.2	18	89	13	20	6.8	7.4	1
3	Tyler Badie T. Badie	1,604	2021	MIZ	12	268	6.0	133.7	14	330	54	74	6.1	27.5	4
4	Tyler Allgeier T. Allgeier	1,601	2021	BYU	13	276	5.8	123.2	23	199	28	39	7.1	15.3	0
5	Abram Smith A. Smith	1,601	2021	BAY	14	257	6.2	114.4	12	75	13	19	5.8	5.4	0
6	Sean Tucker S. Tucker	1,496	2021	SYR	12	246	6.1	124.7	12	255	20	27	12.8	21.3	2
7	Sincere McCormick S. McCormick	1,479	2021	UTSA	14	299	4.9	105.6	15	184	22	23	8.4	13.1	0
8	Breece Hall B. Hall	1,472	2021	ISU	12	253	5.8	122.7	20	302	36	42	8.4	25.2	3
9	Bryant Koback B. Koback	1,408	2021	TOL	13	209	6.7	108.3	16	334	29	36	11.5	25.7	2
10	Deuce Vaughn D. Vaughn	1,404	2021	KSU	13	235	6.0	108.0	18	468	49	66	9.6	36.0	4
11	Rasheen Ali R. Ali	1,401	2021	MRSH	13	250	5.6	107.8	23	334	45	57	7.4	25.7	1
12	Christopher Rodriguez Jr. C. Rodriguez Jr.	1,379	2021	UK	13	225	6.1	106.1	9	61	13	19	4.7	4.7	3
13	DeWayne McBride D. McBride	1,371	2021	UAB	13	204	6.7	105.5	13	19	3	5	6.3	1.5	0
14	Brad Roberts B. Roberts	1,356	2021	AFA	13	299	4.5	104.3	13	0	0	1		0.0	0
15	Brian Robinson Jr. B. Robinson Jr.	1,343	2021	ALA	14	271	5.0	95.9	14	296	35	42	8.5	21.1	2
16	B.J. Baylor	1,337	2021	ORST	13	227	5.9	102.8	13	75	8	12	9.4	5.8	0
17	Hassan Haskins H. Haskins	1,327	2021	MICH	14	270	4.9	94.8	20	131	18	23	7.3	9.4	0
18	Jerome Ford J. Ford	1,319	2021	CIN	13	215	6.1	101.5	19	220	21	22	10.5	16.9	1
19	Travis Dye T. Dye	1,271	2021	ORE	14	211	6.0	90.8	16	402	46	55	8.7	28.7	2
20	Braelon Allen B. Allen	1,268	2021	WIS	12	186	6.8	105.7	12	39	8	12	4.9	3.3	0
21	Charles Williams C. Williams	1,261	2021	UNLV	12	254	5.0	105.1	15	202	13	17	15.5	16.8	0
22	Kennedy Brooks K. Brooks	1,253	2021	OKLA	13	198	6.3	96.4	13	73	9	11	8.1	5.6	0
23	TreVeyon Henderson T. Henderson	1,248	2021	OSU	13	183	6.8	96.0	15	312	27	30	11.6	24.0	4
24	Mataeo Durant M. Durant	1,233	2021	DUKE	12	256	4.8	102.8	9	256	27	32	9.5	21.3	2
25	Jaylen Warren J. Warren	1,216	2021	OKST	14	256	4.8	86.9	11	225	25	33	9.0	16.1	0