Travis Etienne had the most games with 20+ rushing yards, with 54 games.

Interpreted as:

Most 20+ rushing yard games by a player

	NAME	GP	RUSH YDS	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Travis Etienne T. Etienne	54	4,933	678	7.3	91.4	70	1,155	102	128	11.3	21.4	8
2	Toa Taua T. Taua	53	3,910	801	4.9	73.8	33	1,037	146	185	7.1	19.6	3
3	Kaytron Allen K. Allen	52	4,154	756	5.5	79.9	38	489	69	99	7.1	9.4	4
4	Marquez Cooper M. Cooper	51	5,106	1,074	4.8	100.1	45	491	56	77	8.8	9.6	2
5	Roman Hemby R. Hemby	50	3,396	671	5.1	67.9	28	909	112	133	8.1	18.2	4
6	Travis Dye T. Dye	50	3,928	637	6.2	78.6	30	1,044	100	124	10.4	20.9	8
7	Myles Gaskin M. Gaskin	50	5,302	935	5.7	106.0	57	466	64	90	7.3	9.3	5
8	Royce Freeman R. Freeman	50	5,611	932	6.0	112.2	60	814	79	91	10.3	16.3	4
9	Justin Jackson J. Jackson	50	5,422	1,135	4.8	108.4	40	834	121	163	6.9	16.7	1
10	Donnel Pumphrey D. Pumphrey	50	6,361	1,045	6.1	127.2	62	961	95	120	10.1	19.2	4
11	Damion Fletcher D. Fletcher	50	5,302	1,009	5.3	106.0	44	904	109		8.3	18.1	2
12	Noah Whittington N. Whittington	49	2,867	488	5.9	58.5	20	488	75	98	6.5	10.0	4
13	Tahj Brooks T. Brooks	49	4,544	867	5.2	92.7	45	492	96	122	5.1	10.0	2
14	Rodney Smith R. Smith	49	4,101	870	4.7	83.7	29	510	64	82	8.0	10.4	0
15	Johnathan Franklin J. Franklin	49	4,382	772	5.7	89.4	31	451	54		8.4	9.2	2
16	Tim Tebow T. Tebow	49	2,932	654	4.5	59.8	50
17	Nicholas Singleton N. Singleton	48	3,375	590	5.7	70.3	42	868	88	121	9.9	18.1	9
18	Diego Pavia D. Pavia	48	3,107	610	5.1	64.7	31	0	0	0		0.0	0
19	Devin Neal D. Neal	48	4,342	759	5.7	90.5	49	711	77	101	9.2	14.8	4
20	Jarvion Franklin J. Franklin	48	4,845	925	5.2	100.9	52	661	60	72	11.0	13.8	4
21	Ralph Webb R. Webb	48	4,159	920	4.5	86.6	32	569	67	116	8.5	11.9	3
22	Jahwan Edwards J. Edwards	48	4,558	884	5.2	95.0	51	361	57		6.3	7.5	0
23	Colin Kaepernick C. Kaepernick	48	4,090	584	7.0	85.2	58	6	1		6.0	0.1	1
24	Cedric Benson C. Benson	48	5,540	1,112	5.0	115.4	64	621	69		9.0	12.9	3
25	Nate Noel N. Noel	47	3,808	669	5.7	81.0	20	262	54	70	4.9	5.6	0