Between the 2005 and 2012 seasons, Damion Fletcher rushed for the most yards, with 5,302 yards.

Most rushing yards by a player from 2005 to 2012

	NAME	RUSH YDS	GP	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	AVG	REC YDS/G	REC TD
1	Damion Fletcher D. Fletcher	5,302	50	1,009	5.3	106.0	44	904	109	8.3	18.1	2
2	Montee Ball M. Ball	5,140	49	924	5.6	104.9	77	598	59	10.1	12.2	6
3	LaMichael James L. James	5,082	37	771	6.6	137.4	53	586	51	11.5	15.8	4
4	Ray Rice R. Rice	4,926	38	910	5.4	129.6	49	334	37	9.0	8.8	1
5	Montel Harris M. Harris	4,789	50	973	4.9	95.8	39	467	59	7.9	9.3	3
6	Kevin Smith K. Smith	4,679	36	905	5.2	130.0	45	444	55	8.1	12.3	1
7	Robbie Rouse R. Rouse	4,647	49	898	5.2	94.8	37	794	110	7.2	16.2	5
8	Tyrell Fenroy T. Fenroy	4,642	46	808	5.7	100.9	48	585	60	9.8	12.7	1
9	Darren McFadden D. McFadden	4,590	38	785	5.8	120.8	41	365	46	7.9	9.6	2
10	Vai Taua V. Taua	4,588	41	711	6.5	111.9	45	571	61	9.4	13.9	8
11	Bobby Rainey B. Rainey	4,542	43	895	5.1	105.6	35	682	80	8.5	15.9	5
12	Denard Robinson D. Robinson	4,498	48	722	6.2	93.7	42	31	3	10.3	0.6	0
13	Pat White P. White	4,480	49	684	6.5	91.4	47
14	Johnathan Franklin J. Franklin	4,403	53	788	5.6	83.1	31	517	58	8.9	9.8	3
15	Javon Ringer J. Ringer	4,398	45	843	5.2	97.7	34	719	96	7.5	16.0	1
16	Noel Devine N. Devine	4,317	51	729	5.9	84.6	29	710	98	7.2	13.9	2
17	Stepfan Taylor S. Taylor	4,300	52	843	5.1	82.7	40	778	97	8.0	15.0	5
18	Lance Dunbar L. Dunbar	4,224	41	782	5.4	103.0	41	1,033	97	10.6	25.2	8
19	Zach Line Z. Line	4,185	50	778	5.4	83.7	47	599	75	8.0	12.0	0
20	Ian Johnson I. Johnson	4,184	49	752	5.6	85.4	58	642	60	10.7	13.1	1
21	Kendall Hunter K. Hunter	4,181	46	708	5.9	90.9	37	519	63	8.2	11.3	2
22	Colin Kaepernick C. Kaepernick	4,112	51	600	6.9	80.6	59	6	1	6.0	0.1	1
23	Chris Polk C. Polk	4,049	40	799	5.1	101.2	26	683	79	8.6	17.1	4
24	Anthony Dixon A. Dixon	3,994	48	910	4.4	83.2	42	449	56	8.0	9.4	4
25	P.J. Hill	3,942	37	770	5.1	106.5	42	358	39	9.2	9.7	2