Since 2000, the Ohio State Buckeyes have had their lowest point differential in a game against USC on September 13, 2008, with a -32-point differential.

ohio state largest losses in a game of all-time, since 2000

	TEAM	DIFF	DATE	TM		OPP	RESULT	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	Ohio State	-32	9/13/2008	OSU	@	USC	L 3-35	0
2	Ohio State	-31	11/4/2017	OSU	@	IOWA	L 24-55	3	20	371	487	40.0	100.0
3	Ohio State	-31	12/31/2016	OSU	@	CLEM	L 0-31	0	9	215	470	21.4	0.0
4	Ohio State	-29	10/20/2018	OSU	@	PUR	L 20-49	2	31	546	539	50.0	66.7
5	Ohio State	-28	1/11/2021	OSU	@	ALA	L 24-52	3	19	341	621	42.9	0.0
6	Ohio State	-27	1/8/2007	OSU	@	FLA	L 14-41	2	8	82	370
7	Ohio State	-26	10/16/2004	OSU	@	IOWA	L 7-33	1	12	177	448
8	Ohio State	-22	11/26/2022	OSU	vs	MICH	L 23-45	2	23	492	530	31.3	0.0
9	Ohio State	-18	9/17/2011	OSU	@	MIA	L 6-24	0
10	Ohio State	-15	11/27/2021	OSU	@	MICH	L 27-42	3	23	458	487	44.4	75.0
11	Ohio State	-15	9/9/2017	OSU	vs	OKLA	L 16-31	1	21	350	490	46.7	0.0
12	Ohio State	-14	9/6/2014	OSU	vs	VT	L 21-35	3	20	342	324	25.0	100.0
13	Ohio State	-14	1/7/2008	OSU	@	LSU	L 24-38	3	17	353	326
14	Ohio State	-14	11/22/2003	OSU	@	MICH	L 21-35	3	22	383	448
15	Ohio State	-13	10/16/2010	OSU	@	WIS	L 18-31	2
16	Ohio State	-12	11/17/2001	OSU	vs	ILL	L 22-34	3	20	430	390
17	Ohio State	-12	11/18/2000	OSU	vs	MICH	L 26-38	3	22	400	391
18	Ohio State	-12	10/14/2000	OSU	vs	MINN	L 17-29	2	13	200	381
19	Ohio State	-11	12/29/2023	OSU	vs	MIZ	L 3-14	0	12	203	331	13.3	100.0
20	Ohio State	-11	10/9/2004	OSU	vs	WIS	L 13-24	1	12	224	344
21	Ohio State	-10	12/31/2025	OSU	vs	MIA	L 14-24	2	18	332	291	30.0	100.0
22	Ohio State	-10	12/7/2013	OSU	@	MSU	L 24-34	3	21	374	438	10.0	0.0
23	Ohio State	-8	10/17/2009	OSU	@	PUR	L 18-26	2
24	Ohio State	-7	9/11/2021	OSU	vs	ORE	L 28-35	4	32	612	505	40.0	40.0
25	Ohio State	-7	1/3/2014	OSU	vs	CLEM	L 33-40	5	30	427	576	23.1	100.0