Manchester City have the highest goal differential by a club in the Premier League in a season, with a differential of 79 goals in 2017-18.

biggest goal difference in a premier league season

CLUB	GD	SEASON	M	W	D	L	G	GC	XG	XGA	SH	SOT	PASS-ATT	PASS	POSS%	FOUL	YC	RC
Man City	79	2017-18	38	32	4	2	106	27	83.24	22.59	665	265	27,227	25,142	71.8	344	63	2
Man City	73	2021-22	38	29	6	3	99	26	86.90	25.39	713	253	25,882	23,218	68.4	320	42	1
Man City	72	2018-19	38	32	2	4	95	23	80.13	25.43	683	260	26,822	23,872	68.3	328	44	1
Chelsea	71	2009-10	38	27	5	6	103	32			834	288	18,852		59.3	473	60	5
Liverpool	68	2021-22	38	28	8	2	94	26	87.55	33.10	729	257	23,308	19,817	63.3	363	50	1
Man City	67	2019-20	38	26	3	9	102	35	91.07	33.47	745	265	26,159	23,372	66.9	361	64	4
Liverpool	67	2018-19	38	30	7	1	89	22	73.97	31.58	575	226	23,874	20,198	62.3	315	41	2
Man City	65	2013-14	38	27	5	6	102	37			673	238	20,761		57.6	396	74	1
Man City	64	2011-12	38	28	5	5	93	29			738	250	20,863		58.2	430	59	5
Arsenal	62	2023-24	38	28	5	5	91	29	74.94	28.11	656	227	21,151	18,391	58.5	391	64	2
Man City	62	2023-24	38	28	7	3	96	34	76.40	35.00	694	278	26,304	23,804	65.7	287	53	2
Man City	61	2022-23	38	28	5	5	94	33	75.69	30.80	600	219	25,034	22,359	65.4	347	44	1
Tottenham	60	2016-17	38	26	8	4	86	26	66.57	32.54	669	257	20,150	16,623	60.5	432	62	0
Man United	58	2009-10	38	27	4	7	86	28			695	221	19,318		58.1	446	55	4
Man United	58	2007-08	38	27	6	5	80	22			696	260	17,422		57.8	425	51	2
Chelsea	57	2004-05	38	29	8	1	72	15									53	0
Man United	56	2011-12	38	28	5	5	89	33			646	243	20,193		57.7	389	51	1
Man United	56	2006-07	38	28	5	5	83	27			698	256	18,723		59.2	457	60	1
Liverpool	52	2019-20	38	32	3	3	85	33	67.74	38.49	590	231	23,610	19,899	63.4	331	38	1
Chelsea	52	2016-17	38	30	3	5	85	33	58.99	27.83	580	204	20,125	16,880	55.0	395	72	0
Man United	52	1999-00	38	28	7	3	97	45									42	4
Man City	51	2020-21	38	27	5	6	83	32	70.59	31.61	600	219	25,421	22,722	63.9	361	46	2
Liverpool	51	2013-14	38	26	6	6	101	50			651	258	19,599		55.8	411	54	1
Arsenal	51	2004-05	38	25	8	5	87	36									45	1
Liverpool	50	2008-09	38	25	11	2	77	27			736	224	19,508		59.6	456	50	0