5 players are tied for having the most goals in a Premier League match, with 5 goals. The first three are Sergio Agüero on October 3, 2015, Dimitar Berbatov on November 27, 2010 and Jermain Defoe on November 22, 2009.

the most goals by a player scored in one lacrosse game

NAME	G	DATE	CLUB		OPP	MIN	A	XG	XA	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF	FOUL	YC	RC
Sergio Agüero	5	10/3/2015	Man City	vs	Newcastle	66	0	2.03	0.00	0	0	8	5	1	36	0	1	0	0	0
Dimitar Berbatov	5	11/27/2010	Man United	vs	Rovers	90	0			0									0	0
Jermain Defoe	5	11/22/2009	Tottenham	vs	Wigan Athletic	90	0			0									0	0
Alan Shearer	5	9/19/1999	Newcastle	vs	Sheffield Wed	90	1			2									0	0
Andrew Cole	5	3/4/1995	Man United	vs	Ipswich Town	90	0			0									0	0
Erling Haaland	4	5/4/2024	Man City	vs	Wolves	82	0	2.44	0.00	2	0	8	7	0	32	10	1	0	0	0
Cole Palmer	4	4/15/2024	Chelsea	vs	Everton	80	0	1.47	0.00	1	0	5	5	0	50	6	0	0	0	0
Kevin De Bruyne	4	5/11/2022	Man City	@	Wolves	90	0	0.73	0.37	0	0	6	4	1	73	6	0	2	1	0
Gabriel Jesus	4	4/23/2022	Man City	vs	Watford	90	1	1.96	0.30	1	0	6	4	0	61	11	0	1	0	0
Son Heung-Min	4	9/20/2020	Tottenham	@	Southampton	90	0	1.47	0.25	0	0	4	4	0	40	6	4	0	0	0
Michail Antonio	4	7/11/2020	West Ham	@	Norwich City	78	0	1.97	0.22	0	0	9	6	0	44	14	0	1	0	0
Mohamed Salah	4	3/17/2018	Liverpool	vs	Watford	90	1	1.20	0.96	0	0	4	4	0	56	13	1	1	0	0
Sergio Agüero	4	2/10/2018	Man City	vs	Leicester City	90	0	1.38	0.01	0	0	7	4	0	49	9	0	0	0	0
Harry Kane	4	5/18/2017	Tottenham	@	Leicester City	90	1	1.26	0.12	0	0	10	5	0	51	8	0	0	0	0
Romelu Lukaku	4	2/4/2017	Everton	vs	Bournemouth	90	0	1.19	0.25	0	0	5	4	0	53	14	3	0	0	0
Georginio Wijnaldum	4	10/18/2015	Newcastle	vs	Norwich City	90	0	1.02	0.07	0	0	5	4	0	59	0	0	1	0	0
Sergio Agüero	4	10/18/2014	Man City	vs	Tottenham	90	0			2	0	11	8	0	51	0	1	0	0	0
Luis Suárez	4	12/4/2013	Liverpool	vs	Norwich City	90	1			0									0	0
Yakubu	4	12/3/2011	Rovers	vs	Swansea	87	0			1									0	0
Edin Džeko	4	8/28/2011	Man City	@	Tottenham	90	0			0									0	0
Louis Saha	4	2/5/2011	Everton	vs	Blackpool	86	0			0									0	0
Frank Lampard	4	3/27/2010	Chelsea	vs	Aston Villa	90	1			2									0	0
Wayne Rooney	4	1/23/2010	Man United	vs	Hull City	90	0			0									1	0
Robbie Keane	4	9/26/2009	Tottenham	vs	Burnley	90	0			1									0	0
Andrey Arshavin	4	4/21/2009	Arsenal	@	Liverpool	90	0			0									0	0