Lou Gehrig had his most strikeouts in a game 13 times, with 3 strikeouts.

Interpreted as:

Lou Gehrig has most career strikeouts in a regular-season game

NAME	SO	DATE	TM		OPP	AB	R	H	2B	3B	HR	RBI	SH	SB	CS	BB	HBP	PA	TB	XBH
Lou Gehrig	3	9/2/1937	NYY	@	CLE	3	0	0	0	0	0	0	0	0	0	1	0	4	0	0
Lou Gehrig	3	8/25/1931	NYY	@	CWS	5	0	1	0	0	0	1	0	0	0	0	0	5	1	0
Lou Gehrig	3	7/23/1930	NYY	@	CLE	4	1	1	1	0	0	0	0	0	0	1	0	5	2	1
Lou Gehrig	3	6/27/1930	NYY	vs	CLE	5	0	1	0	0	0	2	0	1	0	0	0	5	1	0
Lou Gehrig	3	5/21/1930	NYY	@	PHA	4	0	0	0	0	0	0	0	0	0	0	0	4	0	0
Lou Gehrig	3	8/6/1929	NYY	vs	WSH	5	0	0	0	0	0	0	0	0	0	0	0	5	0	0
Lou Gehrig	3	9/25/1927	NYY	vs	DET	5	0	1	0	0	0	0	0	0	0	0	0	5	1	0
Lou Gehrig	3	6/26/1927	NYY	vs	PHA	4	0	0	0	0	0	0	0	0	0	0	0	4	0	0
Lou Gehrig	3	6/25/1927	NYY	vs	PHA	5	1	2	1	0	0	1	0	0	0	0	0	5	3	1
Lou Gehrig	3	9/8/1926	NYY	vs	BSA	3	0	0	0	0	0	0	0	0	0	1	0	4	0	0
Lou Gehrig	3	7/5/1926	NYY	@	PHA	5	0	0	0	0	0	0	0	0	0	0	0	5	0	0
Lou Gehrig	3	5/28/1926	NYY	vs	PHA	3	0	0	0	0	0	0	0	0	1	1	0	4	0	0
Lou Gehrig	3	7/4/1925	NYY	vs	PHA	5	0	1	0	0	0	0	1	0	0	1	0	7	1	0
Lou Gehrig	2	9/18/1938	NYY	@	SLA	4	1	2	0	0	1	2	0	0	0	0	0	4	5	1
Lou Gehrig	2	8/27/1938	NYY	vs	CLE	4	0	1	0	0	0	0	0	0	0	0	0	4	1	0
Lou Gehrig	2	8/25/1938	NYY	vs	CLE	3	0	0	0	0	0	0	0	0	0	1	0	4	0	0
Lou Gehrig	2	8/16/1938	NYY	@	WSH	5	0	0	0	0	0	0	0	0	0	0	0	5	0	0
Lou Gehrig	2	7/26/1938	NYY	@	SLA	4	0	1	0	0	0	0	0	0	0	1	0	5	1	0
Lou Gehrig	2	7/12/1938	NYY	vs	SLA	4	1	2	0	0	1	1	0	0	0	0	0	4	5	1
Lou Gehrig	2	6/29/1938	NYY	vs	PHA	4	0	0	0	0	0	0	0	0	0	1	0	5	0	0
Lou Gehrig	2	6/19/1938	NYY	@	SLA	5	0	0	0	0	0	1	0	0	0	0	0	5	0	0
Lou Gehrig	2	6/18/1938	NYY	@	SLA	4	0	0	0	0	0	0	0	0	0	0	0	4	0	0
Lou Gehrig	2	5/12/1938	NYY	vs	CLE	4	1	2	0	0	1	2	0	0	0	0	0	4	5	1
Lou Gehrig	2	5/1/1938	NYY	@	WSH	3	0	0	0	0	0	0	0	0	0	1	0	4	0	0
Lou Gehrig	2	4/26/1938	NYY	@	PHA	3	1	1	1	0	0	1	0	0	0	1	0	4	2	1

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Results may be incomplete. StatMuse has complete game-level data for strikeouts going back to the 1916 season.

Some of the information used here was obtained free of charge from Retrosheet.

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