14 players were tied for the most home runs in a game in 2022, with 3 homers. The first three are Kolten Wong on September 22, 2022, Yordan Alvarez on September 16, 2022 and Bo Bichette on September 5, 2022.

Interpreted as:

most home runs by a player in a regular-season game in 2022

	NAME	HR	DATE	TM		OPP	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Kolten Wong K. Wong	3	9/22/2022	MIL	@	CIN	4	3	3	0	0	5	0	0	0	0	0	4	12	3	0	0	0	0
2	Yordan Alvarez Y. Alvarez	3	9/16/2022	HOU	vs	OAK	4	3	4	0	0	3	0	0	0	0	0	4	13	3	0	0	0	0
3	Bo Bichette B. Bichette	3	9/5/2022	TOR	@	BAL	5	3	3	0	0	5	0	0	1	0	0	5	12	3	0	0	0	0
4	Michael Pérez M. Pérez	3	6/30/2022	PIT	vs	MIL	4	3	4	0	0	5	0	0	0	0	0	4	13	3	0	0	0	0
5	Bryan Reynolds B. Reynolds	3	6/29/2022	PIT	@	WSH	5	3	3	0	0	6	0	0	1	0	0	5	12	3	0	0	0	0
6	Isaac Paredes I. Paredes	3	6/21/2022	TBR	vs	NYY	3	3	3	0	0	4	0	1	0	0	0	4	12	3	0	0	0	0
7	Jack Suwinski J. Suwinski	3	6/19/2022	PIT	vs	SFG	3	3	3	0	0	3	1	0	0	0	0	4	12	3	0	0	0	0
8	Lane Thomas L. Thomas	3	6/3/2022	WSH	@	CIN	5	3	3	0	0	4	0	0	0	0	0	5	12	3	0	0	0	0
9	Brendan Rodgers B. Rodgers	3	6/1/2022	COL	vs	MIA	5	4	3	0	0	4	1	0	1	0	0	6	12	3	0	0	0	0
10	Joc Pederson J. Pederson	3	5/24/2022	SFG	vs	NYM	6	3	4	0	0	8	0	0	0	0	0	6	13	3	0	0	0	0
11	Josh Rojas J. Rojas	3	5/20/2022	ARI	@	CHC	5	3	3	0	0	4	0	0	1	0	0	5	12	3	0	0	0	0
12	Trevor Story T. Story	3	5/19/2022	BOS	vs	SEA	4	5	4	0	0	7	1	0	0	1	0	5	13	3	0	0	0	0
13	Anthony Rizzo A. Rizzo	3	4/26/2022	NYY	vs	BAL	4	4	3	0	0	6	1	0	0	0	0	5	12	3	0	0	0	0
14	Vladimir Guerrero Jr. V. Guerrero Jr.	3	4/13/2022	TOR	@	NYY	4	3	4	1	0	4	0	0	0	0	0	4	14	4	0	0	0	0
15	David Villar D. Villar	2	10/5/2022	SFG	@	SDP	4	2	2	0	0	3	0	1	0	0	0	5	8	2	0	0	0	0
16	J.D. Martinez	2	10/5/2022	BOS	vs	TBR	3	2	2	0	0	4	0	0	0	0	0	3	8	2	0	0	0	0
17	Kyle Schwarber K. Schwarber	2	10/3/2022	PHI	@	HOU	3	2	2	0	0	2	2	0	0	0	0	5	8	2	0	0	0	0
18	Teoscar Hernández T. Hernández	2	10/2/2022	TOR	vs	BOS	4	2	3	0	0	3	0	0	1	0	0	4	9	2	0	0	0	0
19	Shea Langeliers S. Langeliers	2	10/2/2022	OAK	@	SEA	4	2	2	0	0	4	1	0	0	0	0	5	8	2	0	0	0	0
20	Kyle Schwarber K. Schwarber	2	10/1/2022	PHI	@	WSH	4	2	3	0	0	2	1	0	1	0	0	5	9	2	0	0	0	0
21	Evan Longoria E. Longoria	2	9/30/2022	SFG	vs	ARI	4	2	2	0	0	5	0	0	1	0	0	4	8	2	0	0	0	0
22	Mitch Haniger M. Haniger	2	9/29/2022	SEA	vs	TEX	5	2	2	0	0	4	0	0	3	0	0	5	8	2	0	0	0	0
23	Marcus Semien M. Semien	2	9/29/2022	TEX	@	SEA	5	2	2	0	0	4	0	0	2	0	0	6	8	2	0	1	0	0
24	Jarred Kelenic J. Kelenic	2	9/29/2022	SEA	vs	TEX	5	3	2	0	0	3	0	0	2	0	0	5	8	2	0	0	0	0
25	Ronald Acuña Jr. R. Acuña Jr.	2	9/27/2022	ATL	@	WSH	5	2	2	0	0	2	0	0	2	0	0	5	8	2	0	0	0	0