The Washington Senators gave up their most runs in a game versus the Red Sox on September 27, 1940, with 24 runs.

Interpreted as:

most runs allowed regular-season game of twins

	TEAM	R	DATE	TM		OPP	RESULT	ERA	SO	SHO	SV	IP	H	ER	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Senators	24	9/27/1940	WSH	@	BSA	L 4-24	0.00	6	0	0	8.0	22	0	2	9	0		53	1	6.75	10.13	0.67	2.25	11.3	17.0	3.88	.556	27.00	24.75
2	Twins	23	4/6/1974	MIN	@	KCR	L 6-23	22.50	5	0	0	8.0	16	20	2	9	1	0	52	2	5.63	10.13	0.56	2.25	9.6	17.3	3.13	.400	25.88	18.00
3	Senators	22	8/12/1953	WSH	vs	NYY	L 1-22	22.00	2	0	0	9.0	28	22	1	7	0	0	61	1	2.00	7.00	0.29	1.00	3.3	11.5	3.89	.529	22.00	28.00
4	Senators	22	8/7/1923	WSH	vs	CLE	L 2-22	0.00	2	0	0	9.0	26	0	0	8	0		56	1	2.00	8.00	0.25	0.00	3.6	14.3	3.78	.565	22.00	26.00
5	Senators	21	7/4/1927	WSH	@	NYY	L 1-21	0.00	2	0	0	8.0	19	0	3	11	0		54	1	2.25	12.38	0.18	3.38	3.7	20.4	3.75	.421	23.63	21.38
6	Senators	21	5/29/1912	WSH	@	BSA	L 8-21	0.00	3	0	0	8.0	18	0	1	11	1		53	2	3.38	12.38	0.27	1.13	5.7	20.8	3.63	.459	23.63	20.25
7	Twins	20	7/25/2011	MIN	@	TEX	L 6-20	18.00	4	0	0	8.0	27	16	2	4	0	1	57	1	4.50	4.50	1.00	2.25	7.0	7.0	3.88	.532	22.50	30.38
8	Twins	20	4/25/1961	MIN	@	KCA	L 2-20	21.38	5	0	0	8.0	16	19	0	10	0	1	50	2	5.63	11.25	0.50	0.00	10.0	20.0	3.25	.457	22.50	18.00
9	Senators	20	6/17/1956	WSH	@	CWS	L 2-20	21.38	2	0	0	8.0	21	19	1	6	0	0	51	2	2.25	6.75	0.33	1.13	3.9	11.8	3.38	.476	22.50	23.63
10	Senators	20	9/11/1949	WSH	@	NYY	L 5-20	18.00	4	0	0	8.0	17	16	0	17	0		56	0	4.50	19.13	0.24	0.00	7.1	30.4	4.25	.486	22.50	19.13
11	Senators	20	5/11/1911	WSH	@	CWS	L 6-20	0.00	4	0	0	8.0	21	0	1	2	2		51	1	4.50	2.25	2.00	1.13	7.8	3.9	2.88	.476	22.50	23.63
12	Senators	20	8/31/1906	WSH	@	NYH	L 5-20	0.00	3	0	0	6.0	21	0	2	3	2			0	4.50	4.50	1.00	3.00			4.00		30.00	31.50
13	Twins	19	7/14/2018	MIN	vs	TBR	L 6-19	19.00	7	0	0	9.0	20	19	3	4	1	1	50	1	7.00	4.00	1.75	3.00	14.0	8.0	2.67	.486	19.00	20.00
14	Twins	19	5/24/2008	MIN	@	DET	L 3-19	20.25	5	0	0	8.0	17	18	2	5	0	0	48	1	5.63	5.63	1.00	2.25	10.4	10.4	2.75	.417	21.38	19.13
15	Twins	19	7/13/1996	MIN	vs	CLE	L 11-19	19.00	7	0	0	9.0	22	19	3	5	1	0	54	3	7.00	5.00	1.40	3.00	13.0	9.3	3.00	.500	19.00	22.00
16	Twins	19	8/4/1992	MIN	@	CWS	L 11-19	21.38	4	0	0	8.0	19	19	3	7	0	0	50	0	4.50	7.88	0.57	3.38	8.0	14.0	3.25	.444	21.38	21.38
17	Senators	19	4/13/1955	WSH	@	NYY	L 1-19	20.25	3	0	0	8.0	16	18	3	8	3	0	52	1	3.38	9.00	0.38	3.38	5.8	15.4	3.00	.371	21.38	18.00
18	Senators	19	4/24/1906	WSH	vs	BSA	L 2-19	0.00	2	0	0	9.0	20	0	0	4	0			0	2.00	4.00	0.50	0.00			2.67		19.00	20.00
19	Senators	19	5/7/1903	WSH	@	PHA	L 5-19	0.00	3	0	0	8.0	22	0	2	4	0	-10	53	1	3.38	4.50	0.75	2.25	5.7	7.5	3.25	.455	21.38	24.75
20	Twins	18	9/2/2018	MIN	@	TEX	L 4-18	18.00	8	0	0	8.0	19	16	6	2	3	0	48	0	9.00	2.25	4.00	6.75	16.7	4.2	2.63	.448	20.25	21.38
21	Twins	18	9/11/2013	MIN	vs	OAK	L 3-18	16.00	6	0	0	9.0	22	16	3	4	1	0	53	0	6.00	4.00	1.50	3.00	11.3	7.5	2.89	.487	18.00	22.00
22	Twins	18	7/9/2008	MIN	@	BOS	L 5-18	20.25	4	0	0	8.0	23	18	2	2	0	0	49	0	4.50	2.25	2.00	2.25	8.2	4.1	3.13	.512	20.25	25.88
23	Twins	18	4/29/2006	MIN	@	DET	L 1-18	18.00	10	0	0	8.0	23	16	4	2	1	0	51	3	11.25	2.25	5.00	4.50	19.6	3.9	3.13	.559	20.25	25.88
24	Twins	18	6/11/1996	MIN	vs	SEA	L 8-18	16.00	7	0	0	9.0	24	16	1	3	1	0	55	2	7.00	3.00	2.33	1.00	12.7	5.5	3.00	.535	18.00	24.00
25	Twins	18	4/18/1988	MIN	vs	NYY	L 5-18	17.00	10	0	0	9.0	20	17	3	7	0	2	55	0	10.00	7.00	1.43	3.00	18.2	12.7	3.00	.486	18.00	20.00